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The novel angiotensin-I-converting enzyme inhibitory peptides from Scomber japonicus muscle protein hydrolysates: QSAR-based screening, molecular docking, kinetic and stability studies.
Wang, Baobei; Zhang, Hui; Wen, Yuxi; Yuan, Wenwen; Chen, Hongbin; Lin, Luan; Guo, Fengxian; Zheng, Zong-Ping; Zhao, Chao.
Afiliação
  • Wang B; Fujian Province Key Laboratory for the Development of Bioactive Material from Marine Algae, College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou 362000, China; Key Laboratory of Inshore Resources and Biotechnology Fujian Province University, Quanzhou 362000, China. Electronic
  • Zhang H; Fujian Province Key Laboratory for the Development of Bioactive Material from Marine Algae, College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou 362000, China; College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China. Electronic add
  • Wen Y; College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China; State Key Laboratory of Mariculture Breeding, Key Laboratory of Marine Biotechnology of Fujian Province, Fujian Agriculture and Forestry University, Fuzhou 350002, China. Electronic address: yuxi.we
  • Yuan W; Fujian Province Key Laboratory for the Development of Bioactive Material from Marine Algae, College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou 362000, China. Electronic address: 1459807064@qq.com.
  • Chen H; Fujian Province Key Laboratory for the Development of Bioactive Material from Marine Algae, College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou 362000, China; Key Laboratory of Inshore Resources and Biotechnology Fujian Province University, Quanzhou 362000, China. Electronic
  • Lin L; Fujian Province Key Laboratory for the Development of Bioactive Material from Marine Algae, College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou 362000, China; Key Laboratory of Inshore Resources and Biotechnology Fujian Province University, Quanzhou 362000, China. Electronic
  • Guo F; Fujian Province Key Laboratory for the Development of Bioactive Material from Marine Algae, College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou 362000, China; Key Laboratory of Inshore Resources and Biotechnology Fujian Province University, Quanzhou 362000, China. Electronic
  • Zheng ZP; Fujian Province Key Laboratory for the Development of Bioactive Material from Marine Algae, College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou 362000, China; Key Laboratory of Inshore Resources and Biotechnology Fujian Province University, Quanzhou 362000, China. Electronic
  • Zhao C; College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China; State Key Laboratory of Mariculture Breeding, Key Laboratory of Marine Biotechnology of Fujian Province, Fujian Agriculture and Forestry University, Fuzhou 350002, China. Electronic address: zhchao@
Food Chem ; 447: 138873, 2024 Jul 30.
Article em En | MEDLINE | ID: mdl-38452536
ABSTRACT
Food-derived angiotensin-converting enzyme-inhibitory (ACE-I) peptides have attracted extensive attention. Herein, the ACE-I peptides from Scomber japonicus muscle hydrolysates were screened, and their mechanisms of action and inhibition stability were explored. The quantitative structure-activity relationship (QSAR) model based on 5z-scale metrics was developed to rapidly screen for ACE-I peptides. Two novel potential ACE-I peptides (LTPFT, PLITT) were predicted through this model coupled with in silico screening, of which PLITT had the highest activity (IC50 48.73 ± 7.59 µM). PLITT inhibited ACE activity with a mixture of non-competitive and competitive mechanisms, and this inhibition mainly contributed to the hydrogen bonding based on molecular docking study. PLITT is stable under high temperatures, pH, glucose, and NaCl. The zinc ions (Zn2+) and copper ions (Cu2+) enhanced ACE-I activity. The study suggests that the QSAR model is effective in rapidly screening for ACE-I inhibitors, and PLITT can be supplemented in foods to lower blood pressure.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hidrolisados de Proteína / Relação Quantitativa Estrutura-Atividade Idioma: En Revista: Food Chem Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hidrolisados de Proteína / Relação Quantitativa Estrutura-Atividade Idioma: En Revista: Food Chem Ano de publicação: 2024 Tipo de documento: Article