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Ginkgolides with anti-PAF activity from Ginkgo biloba L.
Zhang, Jing; Chen, Sha; Sun, Peng; Liu, Yan; Jiang, Jinzhu; Guo, Cong; Cheng, Jintang; Liu, Xianju; Zhang, Jun; Chen, Chang; Di, Jipeng; Liu, An; Xu, Qingxia.
Afiliação
  • Zhang J; Institute of Chinese Materia Medica and Artemisinin Research Center, China Academy of Chinese Medical Sciences, No. 16, Nanxiaojie, Dongzhimennei, Beijing 100700, China.
  • Chen S; Institute of Chinese Materia Medica and Artemisinin Research Center, China Academy of Chinese Medical Sciences, No. 16, Nanxiaojie, Dongzhimennei, Beijing 100700, China.
  • Sun P; Institute of Chinese Materia Medica and Artemisinin Research Center, China Academy of Chinese Medical Sciences, No. 16, Nanxiaojie, Dongzhimennei, Beijing 100700, China.
  • Liu Y; Institute of Chinese Materia Medica and Artemisinin Research Center, China Academy of Chinese Medical Sciences, No. 16, Nanxiaojie, Dongzhimennei, Beijing 100700, China.
  • Jiang J; Institute of Chinese Materia Medica and Artemisinin Research Center, China Academy of Chinese Medical Sciences, No. 16, Nanxiaojie, Dongzhimennei, Beijing 100700, China.
  • Guo C; Institute of Chinese Materia Medica and Artemisinin Research Center, China Academy of Chinese Medical Sciences, No. 16, Nanxiaojie, Dongzhimennei, Beijing 100700, China.
  • Cheng J; Institute of Chinese Materia Medica and Artemisinin Research Center, China Academy of Chinese Medical Sciences, No. 16, Nanxiaojie, Dongzhimennei, Beijing 100700, China.
  • Liu X; Institute of Chinese Materia Medica and Artemisinin Research Center, China Academy of Chinese Medical Sciences, No. 16, Nanxiaojie, Dongzhimennei, Beijing 100700, China.
  • Zhang J; Institute of Chinese Materia Medica and Artemisinin Research Center, China Academy of Chinese Medical Sciences, No. 16, Nanxiaojie, Dongzhimennei, Beijing 100700, China.
  • Chen C; Institute of Chinese Materia Medica and Artemisinin Research Center, China Academy of Chinese Medical Sciences, No. 16, Nanxiaojie, Dongzhimennei, Beijing 100700, China.
  • Di J; Institute of Chinese Materia Medica and Artemisinin Research Center, China Academy of Chinese Medical Sciences, No. 16, Nanxiaojie, Dongzhimennei, Beijing 100700, China.
  • Liu A; Institute of Chinese Materia Medica and Artemisinin Research Center, China Academy of Chinese Medical Sciences, No. 16, Nanxiaojie, Dongzhimennei, Beijing 100700, China. Electronic address: aliu@icmm.ac.cn.
  • Xu Q; Institute of Chinese Materia Medica and Artemisinin Research Center, China Academy of Chinese Medical Sciences, No. 16, Nanxiaojie, Dongzhimennei, Beijing 100700, China. Electronic address: qxxu@icmm.ac.cn.
Fitoterapia ; 175: 105915, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38508499
ABSTRACT
Four undescribed ginkgolides, including two rare sesquiterpene ginkgolides (compounds 1 and 2) and two diterpenoid ginkgolides (compounds 3 and 4), were isolated from Ginkgo biloba L. The structures of these four ginkgolides were identified based on extensive spectroscopic analysis, DP4+ probability analysis and X-ray diffraction. Compounds 1 and 2 exhibited excellent antiplatelet aggregation activities with IC50 values of 1.20 ± 0.25 and 4.11 ± 0.34 µM, respectively.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores da Agregação Plaquetária / Ginkgo biloba / Ginkgolídeos / Compostos Fitoquímicos Idioma: En Revista: Fitoterapia Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores da Agregação Plaquetária / Ginkgo biloba / Ginkgolídeos / Compostos Fitoquímicos Idioma: En Revista: Fitoterapia Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China