α-Linolenic Acid Induces Microglial Activation and Extracellular Tau Internalization.
Methods Mol Biol
; 2754: 471-481, 2024.
Article
em En
| MEDLINE
| ID: mdl-38512683
ABSTRACT
Neuroinflammation is the brain condition that occurs due to the hyper-activation of brain's immune cells and microglia, over the stimulation of extracellular aggregated proteins such as amyloid plaques and by extracellular Tau as well. The phenotypic changes of microglia from inflammatory to anti-inflammatory can be triggered by many factors, which also includes dietary fatty acids. The classes of omega-3 fatty acids are the majorly responsible in maintaining the anti-inflammatory phenotype of microglia. The enhanced phagocytic ability of microglia might induce the clearance of extracellular aggregated proteins, such as amyloid beta and Tau. In this study, we emphasized on the effect of α-linolenic acid (ALA) on the activation of microglia and internalization of the extracellular Tau seed in microglia.
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Base de dados:
MEDLINE
Assunto principal:
Doença de Alzheimer
Idioma:
En
Revista:
Methods Mol Biol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Índia