Near-Infrared-II Nanomaterials for Activatable Photodiagnosis and Phototherapy.
Chemistry
; 30(33): e202400816, 2024 Jun 12.
Article
em En
| MEDLINE
| ID: mdl-38613472
ABSTRACT
Near-Infrared-II (NIR-II) spans wavelengths between 1,000 to 1,700 nanometers, featuring deep tissue penetration and reduced tissue scattering and absorption characteristics, providing robust support for cancer treatment and tumor imaging research. This review explores the utilization of activatable NIR-II photodiagnosis and phototherapy based on tumor microenvironments (e. g., reactive oxygen species, pH, glutathione, hypoxia) and external stimulation (e. g., laser, ultrasound, photothermal) for precise tumor treatment and imaging. Special emphasis is placed on the advancements and advantages of activatable NIR-II nanomedicines in novel therapeutic modalities like photodynamic therapy, photothermal therapy, and photoacoustic imaging. This encompasses achieving deep tumor penetration, real-time monitoring of the treatment process, and obtaining high-resolution, high signal-to-noise ratio images even at low material concentrations. Lastly, from a clinical perspective, the challenges faced by activatable NIR-II phototherapy are discussed, alongside potential strategies to overcome these hurdles.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Nanoestruturas
/
Raios Infravermelhos
/
Neoplasias
Idioma:
En
Revista:
Chemistry
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China