Targeted metabolomics profiling in pregnancy associated with vitamin D deficiency.
BMC Pregnancy Childbirth
; 24(1): 295, 2024 Apr 20.
Article
em En
| MEDLINE
| ID: mdl-38643102
ABSTRACT
BACKGROUND:
Vitamin D deficiency is common in pregnancy, however, its effects has not been fully elucidated. Here, we conducted targeted metabolomics profiling to study the relationship.METHODS:
This study enrolled 111 pregnant women, including sufficient group (n = 9), inadequate group (n = 49) and deficient group (n = 53). Ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS)-based targeted metabonomics were used to characterize metabolite profiles associated with vitamin D deficiency in pregnancy.RESULTS:
Many metabolites decreased in the inadequate and deficient group, including lipids, amino acids and others. The lipid species included fatty acyls (FA 143, FA 260; O), glycerolipids (MG 182), glycerophospholipids (LPG 205, PE-Cer 401; O2, PG 290), sterol lipids (CE 205, ST 280; O4, ST 281; O4). Decreased amino acids included aromatic amino acids (tryptophan, phenylalanine, tyrosine) and branched-chain amino acids (valine, isoleucine, leucine), proline, methionine, arginine, lysine, alanine, L-kynurenine,5-hydroxy-L-tryptophan, allysine.CONCLUSIONS:
This targeted metabolomics profiling indicated that vitamin D supplementation can significantly affect lipids and amino acids metabolism in pregnancy.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Deficiência de Vitamina D
/
Espectrometria de Massas em Tandem
Idioma:
En
Revista:
BMC Pregnancy Childbirth
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China