Production of the antifungal biopesticide physcion through the combination of microbial fermentation and chemical post-treatment.

Zhuang, Zheng; Zhong, Xueqing; Li, Qinghua; Liu, Tian; Yang, Qing; Lin, Guo-Qiang; He, Qing-Li; Zhao, Qunfei; Liu, Wen

Zhuang, Zheng; Zhong, Xueqing; Li, Qinghua; Liu, Tian; Yang, Qing; Lin, Guo-Qiang; He, Qing-Li; Zhao, Qunfei; Liu, Wen.

Afiliação

Zhuang Z; The Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China.
Zhong X; The Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China.
Li Q; The Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China.
Liu T; School of Bioengineering, Dalian University of Technology, No. 2, Linggong Road, Dalian, 116024, China.
Yang Q; State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, No. 2 West Yuanmingyuan Road, Beijing, 100193, China.
Lin GQ; The Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China.
He QL; The Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China. qinglihe@shutcm.edu.cn.
Zhao Q; The Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China. qunfeizhao@shutcm.edu.cn.
Liu W; State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.

Bioresour Bioprocess ; 10(1): 2, 2023 Jan 09.

Article em En | MEDLINE | ID: mdl-38647644

ABSTRACT

ABSTRACT

Physcion is an anthraquinone compound observed dominantly in medicinal herbs. This anthraquinone possesses a variety of pharmaceutically important activities and has been developed to be a widely used antifungal biopesticide. Herein, we report on the effective preparation of 3R-torosachrysone (4), a tetrahydroanthracene precursor of physcion, in Aspergillus oryzae NSAR1 by heterologous expression of related genes mined from the phlegmacins-producing ascomycete Talaromyces sp. F08Z-0631. Conditions for converting 4 into physcion were studied and optimized, leading to the development of a concise approach for extracting high-purity physcion from the alkali-treated fermentation broth of the 4-producing A. oryzae strain.

Palavras-chave

Antifungal biopesticide; Microbial production; Physcion

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Bioresour Bioprocess Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China