Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review.
J Cancer Res Clin Oncol
; 150(4): 213, 2024 Apr 25.
Article
em En
| MEDLINE
| ID: mdl-38662225
ABSTRACT
Copper is a necessary micronutrient for maintaining the well-being of the human body. The biological activity of organic ligands, especially their anticancer activity, is often enhanced when they coordinate with copper(I) and (II) ions. Copper and its compounds are capable of inducing tumor cell death through various mechanisms of action, including activation of apoptosis signaling pathways by reactive oxygen species (ROS), inhibition of angiogenesis, induction of cuproptosis, and paraptosis. Some of the copper complexes are currently being evaluated in clinical trials for their ability to map tumor hypoxia in various cancers, including locally advanced rectal cancer and bulky tumors. Several studies have shown that copper nanoparticles can be used as effective agents in chemodynamic therapy, phototherapy, hyperthermia, and immunotherapy. Despite the promising anticancer activity of copper-based compounds, their use in clinical trials is subject to certain limitations. Elevated copper concentrations may promote tumor growth, angiogenesis, and metastasis by affecting cellular processes.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cobre
/
Neoplasias
/
Antineoplásicos
Idioma:
En
Revista:
J Cancer Res Clin Oncol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Geórgia