Ventilatory response to CO2 following axillary blockade with bupivacaine.
Anesthesiology
; 63(4): 401-3, 1985 Oct.
Article
em En
| MEDLINE
| ID: mdl-3929649
ABSTRACT
The systemic effect of bupivacaine on the control of ventilation was studied in eight ASA I (six male, two female) unpremedicated healthy subjects aged 30-55 yr (mean 43.5 yr) and weighing 59-82 kg (mean 69 kg) after axillary blockade with bupivacaine 0.5% without epinephrine, 3 mg/kg. The slope of the ventilatory response to CO2 was significantly increased (P less than 0.05) from its control value (1.77 +/- 1.03 l X min-1 X mmHg-1 [mean +/- SD]) 30 min (+19 +/- 32%) and 60 min (+32 +/- 37%) after axillary blockade, while plasma bupivacaine levels were 1.65 +/- 0.82 and 1.40 +/- 0.60 micrograms/ml, respectively. The correlation between individual plasma bupivacaine levels and the changes in the slope of the ventilatory response to CO2 was significant (r = 0.57, n = 16, P less than 0.05). Resting minute ventilation and end-tidal CO2 values did not change significantly. These results suggest that bupivacaine has a systemic stimulating effect on the ventilatory control mechanisms.
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Base de dados:
MEDLINE
Assunto principal:
Respiração
/
Bupivacaína
/
Dióxido de Carbono
/
Anestesia Local
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Anesthesiology
Ano de publicação:
1985
Tipo de documento:
Article