5-(Alkylsulfonyl)salicylanilides as potential dental antiplaque agents.
J Med Chem
; 29(1): 25-9, 1986 Jan.
Article
em En
| MEDLINE
| ID: mdl-3941411
ABSTRACT
A series of 22 5-(alkylsulfonyl)salicylanilides was synthesized and evaluated for in vitro antibacterial and antiplaque activity against Actinomyces viscosus and Streptococcus mutans, adherent microorganisms implicated in periodontal disease and dental caries. The minimum inhibitory concentrations of 25 salicylanilides (including 5-acyl-, 5-alkyl-, and 5-(alkylsulfonyl)-4'-bromo- and -4'-(trifluoromethyl)salicylanilides) were found to correlate (r = 0.94) with estimated log D values. Several salicylanilides, such as 5-(decylsulfonyl)- and 5-(dodecylsulfonyl)-4'-(trifluoromethyl)salicylanilides (15 and 19) were found to exhibit high levels of in vitro antibacterial and antiplaque activity against A. viscosus and S. mutans.
Buscar no Google
Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Plantas_medicinales
Assunto principal:
Salicilanilidas
/
Salicilamidas
/
Placa Dentária
Idioma:
En
Revista:
J Med Chem
Ano de publicação:
1986
Tipo de documento:
Article