Fluorometholone acetate: clinical evaluation in the treatment of external ocular inflammation.
Ann Ophthalmol
; 16(12): 1110-5, 1984 Dec.
Article
em En
| MEDLINE
| ID: mdl-6398026
ABSTRACT
Separate, randomized, double-masked clinical studies were conducted to determine the therapeutic efficacy of fluorometholone acetate, a new ophthalmic corticosteroid formulation, in suppressing external ocular inflammation (conjunctivitis, episcleritis, scleritis). Fluorometholone acetate 0.1% was compared to fluorometholone 0.1%, and the acetate formulation was found to be significantly (p = 0.03) more effective. Fluorometholone acetate 0.1% also was compared to prednisolone acetate 1.0%; there was no significant difference (p = 0.49) between these two corticosteroids in their ability to suppress external ocular inflammation. It appears that alteration of fluorometholone from its alcohol base to its acetate derivative changes the drug from a moderately effective to a highly effective anti-inflammatory agent.
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Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
/
Aromoterapia
Assunto principal:
Oftalmopatias
Tipo de estudo:
Clinical_trials
Idioma:
En
Revista:
Ann Ophthalmol
Ano de publicação:
1984
Tipo de documento:
Article