alpha-Tocopherol protects against radical-induced injury in cultured neurons.
Neurosci Lett
; 170(1): 55-8, 1994 Mar 28.
Article
em En
| MEDLINE
| ID: mdl-8041514
ABSTRACT
The effect of alpha-tocopherol on neurons in protecting against radical-induced injuries caused by cumene hydroperoxide was assessed using a culture system. Structural and biochemical deteriorations in both clonal neuroblastoma cells and primary cultured neurons were induced by cumene hydroperoxide. These deteriorative changes were prevented prevented by pretreatment of alpha-tocopherol. Since simultaneous supplementation of alpha-tocopherol and cumene hydroperoxide had limited protective effects, prophylactic administration of alpha-tocopherol for risk patients with brain diseases concerned with damages induced by free radical is recommended to hamper the progression of neuronal impairment after attacks.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Vitamina E
/
Neurônios
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Japão