[The antithrombotic action of a protein C activator from the venom of Agkistrodon blomhoffi ussuriensis in thrombus formation in an extracorporeal shunt in rats]. / Antitromboticheskoe deistvie aktivatora proteina C iz iada Agkistrodon blomhoffi ussuriensis pri tromboobrazovanii v ékstrakorporal'nom shunte u krys.
Eksp Klin Farmakol
; 57(2): 42-5, 1994.
Article
em Ru
| MEDLINE
| ID: mdl-8205048
ABSTRACT
An antithrombotic action of the protein C (PC) activator from the venom of Agkistrodon blomhoffi ussuriensis on the model of platelet-dependent thrombosis in the arteriovenous shunt in rats was under investigation. Administration of the PC activator to rats resulted in a dose-dependent prolongation of the thrombus formation time, in a decrease in PC and factor V levels in blood and in APTT prolongation. There were no changes in the tissue-type plasminogen activator level and in the ADP- or epinephrine-induced platelet aggregation, but platelet adhesion to glass decreased. The possible mechanism of the antithrombotic action of the PC activator appeared to be the factor V inactivation mediated by protein C activation and the decrease in platelet adhesion.
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Base de dados:
MEDLINE
Assunto principal:
Trombose
/
Proteína C
/
Derivação Arteriovenosa Cirúrgica
/
Agkistrodon
/
Venenos de Crotalídeos
/
Fibrinolíticos
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Idioma:
Ru
Revista:
Eksp Klin Farmakol
Ano de publicação:
1994
Tipo de documento:
Article