Hepatitis B virus in the colostra of HBeAg-positive carrier mothers.
J Pediatr Gastroenterol Nutr
; 17(2): 207-10, 1993 Aug.
Article
em En
| MEDLINE
| ID: mdl-8229550
ABSTRACT
To investigate the amount of hepatitis B virus (HBV) in colostra of hepatitis B e antigen (HBeAg)-positive carrier mothers and the relationship of HBV amount between colostrum and maternal blood, 50 HBeAg-positive carrier mothers were recruited and studied for hepatitis B surface antigen (HBsAg) titer, HBeAg titer, and HBV-DNA concentration in their sera and colostra. According to the presence or absence of seral HBV-DNA determined by dot hybridization, these 50 HBeAg-positive carrier mothers could be divided into two groups group 1 (n = 28, HBV-DNA < 0.04 ng/ml), and group 2 (n = 22, HBV-DNA > or = 0.04 ng/ml). The colostral HBsAg and HBeAg titers were both significantly higher in group 2 than in group 1. In addition, both colostral HBsAg and HBeAg titers had positive correlation with each corresponding maternal blood. Although the colostral HBV-DNA was undetectable by dot hybridization, all were positive by polymerase chain reaction with Southern blot hybridization. Because HBV-DNA can be detected in all HBeAg-positive carrier mother's milk, it reinforces the necessity of hepatitis B vaccination for the neonates born to these carrier mothers, particularly in countries with a high carrier rate.
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Base de dados:
MEDLINE
Assunto principal:
Portador Sadio
/
Vírus da Hepatite B
/
Colostro
/
Hepatite B
/
Antígenos E da Hepatite B
Idioma:
En
Revista:
J Pediatr Gastroenterol Nutr
Ano de publicação:
1993
Tipo de documento:
Article