GABA-gated chloride ion influx in brains of tremor rats.
Neurochem Res
; 18(9): 977-81, 1993 Sep.
Article
em En
| MEDLINE
| ID: mdl-8232726
ABSTRACT
We measured the GABA-gated chloride ion influx and GABA concentrations in the cerebral cortex and the hippocampus of young (5 weeks old) and older (15 weeks old) tremor rats. GABA-gated chloride ion influx in these tremor rats was significantly greater than in the controls of both the 5 week- and 15 week-old groups. GABA concentrations in the cerebral cortex and hippocampus of the tremor rats increased compared with controls of 5 weeks and decreased compared with controls of 15 weeks. These findings suggest that the GABAergic presynaptic neurons in the cortex and hippocampus of the tremor rat are disturbed with aging. This change may be related to the appearance of absence-like seizures in the rats. The increased GABA-gated chloride ion influx in tremor rats may be a compensatory mechanism against the genetically-determined seizure susceptibility of these rats. Furthermore, the increased GABA levels and GABA-gated chloride ion influx found in 5 week-old tremor rats may be related to the tremor movements.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Tremor
/
Encéfalo
/
Ativação do Canal Iônico
/
Cloretos
/
Epilepsia Tipo Ausência
/
Ácido gama-Aminobutírico
/
Neurônios
Idioma:
En
Revista:
Neurochem Res
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Japão