Anti-inflammatory properties and inhibition of leukotriene C4 biosynthesis in vitro by flavonoid baicalein from Scutellaria baicalensis georgy roots.
Agents Actions
; 39 Spec No: C49-51, 1993.
Article
em En
| MEDLINE
| ID: mdl-8273583
ABSTRACT
Anti-inflammatory activity of baicalein (5,6,7-trioxyflavone-7-O-beta-D-glucuronide) was greater in the chronic inflammation model (rat adjuvant arthritis, ED50 = 120.6 mg/kg) than observed in the rat carrageenan-induced paw edema, ED50 > or = 200.0 mg/kg. A comparative study of the 5-lipoxygenase (5-LO) inhibitory activity of baicalein, BW 755 C, and hydroxamic acid arachidonate on leukotriene C4 (LTC4) biosynthesis by rat resident peritoneal macrophages stimulated with calcium ionophore (A 23186) showed that these drugs significantly inhibited LTC4 production, IC50 9.5, 41.8, and 2.8 microM, respectively. This finding suggests that inhibition of the 5-LO pathway of arachidonic acid metabolism may be one of the mechanisms of baicalein's anti-inflammatory activity.
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Base de dados:
MEDLINE
Assunto principal:
Artrite Experimental
/
Flavonoides
/
Inibidores de Lipoxigenase
/
Leucotrieno C4
/
Flavanonas
/
Inflamação
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Agents Actions
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Ucrânia