Inhibitory effects of crude drug components on the proliferation of cultured human mesangial cells.
Nihon Jinzo Gakkai Shi
; 35(4): 321-7, 1993 Apr.
Article
em En
| MEDLINE
| ID: mdl-8341007
ABSTRACT
The effects of a component of an Oriental medicine and green tea plants utilized for the traditional beverage on the proliferation of mesangial cells were determined in terms of the 3H-thymidine uptake. When magnesium lithospermate B was added to the medium of the mesangial cell culture, it suppressed the proliferation of mesangial cells at a concentration of 50 micrograms/ml. The 3H-thymidine uptake began to display an inhibitory action from the 6.25 micrograms/ml (-)-epicatechin 3-O-gallate, (-)-epigallocatechin 3-O-gallate or green tea tannin mixture, showing a more conspicuous inhibition at 50 micrograms/ml that did the magnesium lithospermate B at the corresponding concentration. In particular, (-)-epigallocatechin 3-O-gallate, the predominant component of the green tea tannin mixture, exerted an inhibitory effect at a relatively low concentration.
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Base de dados:
MEDLINE
Medicinas Tradicionais:
Medicinas_tradicionales_de_asia
/
Medicina_china
Assunto principal:
Medicamentos de Ervas Chinesas
/
Mesângio Glomerular
Idioma:
En
Revista:
Nihon Jinzo Gakkai Shi
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Japão