Modulation of interferon-gamma-induced HLA-DR expression on the human keratinocyte cell line SCC-13 by ultraviolet radiation.
Photochem Photobiol
; 57(2): 285-90, 1993 Feb.
Article
em En
| MEDLINE
| ID: mdl-8451291
ABSTRACT
Cell surface expression of major histocompatibility determinants on epidermal keratinocytes is a characteristic feature of a number of inflammatory dermatoses and in all likelihood is caused by diffusion of human leukocyte antigen (HLA)-DR-inducing cytokines from cells present in the dermal mononuclear cell infiltrate. Many of these same disorders respond to ultraviolet (UV) radiation phototherapy. Using the human SCC-13 keratinocyte cell line as a model, UV radiation was found to inhibit interferon-gamma-induced HLA-DR expression. Inhibition correlated closely with decreased steady-state levels of HLA-DR mRNA. These findings provide evidence that the therapeutic effect of UV radiation phototherapy may be mediated by its capacity to down-regulate cytokine-induced keratinocyte HLA-DR expression.
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Base de dados:
MEDLINE
Assunto principal:
Raios Ultravioleta
/
Antígenos HLA-DR
/
Queratinócitos
/
Interferon gama
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Photochem Photobiol
Ano de publicação:
1993
Tipo de documento:
Article