The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil.
Am J Clin Nutr
; 63(1): 116-22, 1996 Jan.
Article
em En
| MEDLINE
| ID: mdl-8604658
ABSTRACT
The effect of a flaxseed oil-based diet on tumor necrosis factor alpha (TNF alpha) and interleukin 1 beta (IL-1 beta) synthesis was examined in healthy volunteers. Use of flaxseed oil in domestic food preparation for 4 wk inhibited TNF alpha and IL-1 beta production by approximately 30%. Fish-oil supplementation (9 g/d) continued for a further 4 wk; TNF alpha and IL-1 beta synthesis were inhibited by 74% and 80%, respectively. There was a significant inverse exponential relation between TNF alpha or IL-1 beta synthesis and mononuclear cell content of eicosapentaenoic acid (EPA), an n--3 fatty acid derived from ingested EPA (fish oil) or metabolism of ingested alpha-linolenic acid (flaxseed oil). Cytokine production decreased as cellular EPA increased to approximately 1% of total fatty acids. Further increases in EPA content did not result in further decreases in cytokine production. The results indicate that vegetable oils rich in n--3 fatty acids inhibit TNF alpha and IL-1 beta synthesis.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Óleos de Plantas
/
Óleos de Peixe
/
Monócitos
/
Ácidos Graxos Ômega-3
/
Interleucina-1
/
Fator de Necrose Tumoral alfa
Idioma:
En
Revista:
Am J Clin Nutr
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Austrália