Changes in androgens during treatment with four low-dose contraceptives.
Contraception
; 53(3): 171-6, 1996 Mar.
Article
em En
| MEDLINE
| ID: mdl-8689882
ABSTRACT
PIP: Health researchers randomly assigned 100 healthy women aged 18-38 from the Netherlands and Saudi Arabia to one of four various oral contraceptive (OC) groups to undergo six cycles of OC therapy so they could evaluate changes in plasma concentrations of sex hormone binding globulin (SHBG), corticosteroid-binding globulin (CBG), albumin (Alb), testosterone (T), free testosterone (FT), dihydrotestosterone (DHT), androstenedione (A), dehydro-epiandrosterone-sulphate (DHEA-S), and 17 alpha-hydroxyprogesterone (17OHP). The four monophasic OCs were Cilest (35 mcg ethinyl estradiol [E2] and 250 mcg norgestimate), Femodeen (30 mcg E2 and 75 mcg gestodene), Marvelon (30 mcg E2 and 150 mcg desogestrel), and Mercilon (20 mcg E2 and 150 mcg desogestrel). There were 12 dropouts. Neither body weight nor blood pressure changed significantly during the study. All steroidal serum parameters (T, FT, DHT, A, DHEA-S, 17OHP, Alb) fell significantly during the six cycles of OC treatment (ratio of decrease, 1.3-3), regardless of OC type. These changes had appeared after cycle 4. The only significant difference between the OC groups was that the mean decrease of DHEA-S for Mercilon was lower than that for the other OC groups (21% vs. 43% for Cilest, 44% for Marvelon, and 34% for Femodeen; p 0.05). SHBG and CBG rose greatly during OC use in all four OC groups (mean increase = 263% and 94%, respectively; p 0.05). The increase in CBG was significantly less in the Mercilon group than in the other OC groups (74% vs. 96% for Cilest, 101% for Femodeen, and 102% for Marvelon; p 0.05). These findings show that OC use changed the endogenous androgen environment in the direction of hypoandrogenism. Thus, all four OCs can equally treat androgen-related syndromes (e.g., acne and hirsutism).
Palavras-chave
Acne; Androgens; Arab Countries; Asia; Biology; Comparative Studies; Contraception; Contraceptive Methods; Dermatitis; Developed Countries; Developing Countries; Diseases; Endocrine System; Europe; Family Planning; Hirsutism; Hormones; Netherlands; Oral Contraceptives; Oral Contraceptives, Low-dose; Physiology; Research Methodology; Research Report; Saudi Arabia; Signs And Symptoms; Studies; Western Asia; Western Europe
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Base de dados:
MEDLINE
Medicinas Complementares:
Homeopatia
Assunto principal:
Anticoncepcionais Orais Combinados
/
Combinação Etinil Estradiol e Norgestrel
/
Androgênios
Tipo de estudo:
Clinical_trials
Idioma:
En
Revista:
Contraception
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Holanda