[The effect of the joint administration of heparin and chitosan sulfate ether on hemostatic function]. / Vliianie sovmestnogo vvedeniia geparina i sernokislogo éfira khitozana na funktsiiu gemostaza.
Eksp Klin Farmakol
; 59(1): 30-3, 1996.
Article
em Ru
| MEDLINE
| ID: mdl-8704629
ABSTRACT
We studied anticoagulant effects of combined administration of heparin (H) and chitosan sulfate ether (CS) (specific activity 20 UE/mg) in the ratio 1 1. CS enhanced anticoagulant activity of heparin in rabbits by a factor of 1.95 +/- 0.15. The intravenous injection of the mixture in a dose of 0.5 mg(H)/kg + 0.5 mg(CS)/kg and heparin injection in a dose of 1mg/kg induced the same effect. Haemorrhagic effect of this mixture was less pronounced compared to heparin, anticoagulant and antithrombotic activities remained the same. The mixture was found to decrease a number of platelets, however, this was also less pronounced compared to heparin. Thus, the use of the mixture CS + H (1 1) instead of double heparin dose resulted in the same effect.
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Base de dados:
MEDLINE
Assunto principal:
Hemostáticos
/
Heparina
/
Quitina
/
Hemostasia
/
Anticoagulantes
Idioma:
Ru
Revista:
Eksp Klin Farmakol
Ano de publicação:
1996
Tipo de documento:
Article