Acute necrotizing myopathy and podophyllin toxicity. Report of a fatal case.
Arq Neuropsiquiatr
; 54(2): 288-92, 1996 Jun.
Article
em En
| MEDLINE
| ID: mdl-8984988
ABSTRACT
A 21 year old male ingested podophyllin in a suicide attempt. The disorder was marked by seizures, coma, peripheral neuropathy, renal failure and acute necrotizing myopathy, an unusual finding. The coma and systemic disturbances resolved within three weeks. The myopathy resolved in 7 weeks, demonstrating a high capacity of muscle recuperation. The sensorimotor peripheral neuropathy persisted until the patient's death 9 weeks after the ingestion, due to septicemia. This report confirms the transient central neurotoxicity of podophyllin and persistent peripheral neurotoxicity of podophyllin, and describes a reversible necrotizing myopathy associated to mitochondrial abnormalities, a still unreported feature of podophyllin toxicity.
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Base de dados:
MEDLINE
Assunto principal:
Podofilina
/
Miopatias Mitocondriais
Idioma:
En
Revista:
Arq Neuropsiquiatr
Ano de publicação:
1996
Tipo de documento:
Article