A case of adrenal insufficiency due to acquired hypothalamic CRH deficiency.
Endocr J
; 44(1): 121-6, 1997 Feb.
Article
em En
| MEDLINE
| ID: mdl-9152624
ABSTRACT
A 40-year-old woman with adrenal insufficiency was clinically diagnosed and examined with human corticotropin releasing hormone (CRH). This patient with secondary hypo-adrenalism has shown a normal serum cortisol response to exogenous ACTH administration and has been examined with CRH, lysine-vasopressin (LVP) and insulin tolerance test (ITT), respectively. Success in secreting ACTH in response to both CRH and LVP tests, but not ITT, suggests that this disorder was possibly due to a hypothalamic CRH deficiency rather than pituitary corticotroph dysfunction. A combination of the CRH test and ITT has come to play an increasingly significant role in the diagnosis and differential diagnosis of isolated ACTH deficiency syndrome.
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Base de dados:
MEDLINE
Assunto principal:
Hormônio Liberador da Corticotropina
/
Insuficiência Adrenal
/
Hipotálamo
Tipo de estudo:
Etiology_studies
Idioma:
En
Revista:
Endocr J
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Japão