Reduction in the incidence and severity of collagen-induced arthritis in DBA/1 mice, using exogenous dehydroepiandrosterone.
Arthritis Rheum
; 40(5): 907-11, 1997 May.
Article
em En
| MEDLINE
| ID: mdl-9153553
ABSTRACT
OBJECTIVE:
This study examined the effect of exogenous dehydroepiandrosterone (DHEA) on the onset, incidence, and severity of collagen-induced arthritis (CIA).METHODS:
DHEA was administered subcutaneously prior to arthritis induction in DBA/1 mice, and the severity of the subsequent arthritis was monitored. Serum levels of total IgG and IgG isotype-specific anti-murine type II collagen were measured.RESULTS:
Repeated administration of DHEA during arthritis induction delayed the onset and decreased the severity of arthritis in male and female DBA/1 mice. DHEA failed to have an observable effect on established arthritis. IgG isotype autoantibody levels were found to be decreased in the sera of DHEA-treated mice.CONCLUSION:
Administration of exogenous DHEA offered protection against the development of CIA. These data support the results of human studies in which low DHEA levels have been identified as a potential risk factor for the development of rheumatoid arthritis. These findings also highlight DHEA as a potential therapy worthy of further investigation.
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Base de dados:
MEDLINE
Assunto principal:
Artrite Experimental
/
Colágeno
/
Desidroepiandrosterona
Tipo de estudo:
Incidence_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Arthritis Rheum
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Reino Unido