Your browser doesn't support javascript.
loading
The influence of silicone implantation on type II collagen-induced arthritis in mice.
Schaefer, C J; Whalen, J D; Knapp, T; Wooley, P H.
Afiliação
  • Schaefer CJ; Wayne State University Medical School, Detroit, Michigan 48201, USA.
Arthritis Rheum ; 40(6): 1064-72, 1997 Jun.
Article em En | MEDLINE | ID: mdl-9182917
ABSTRACT

OBJECTIVE:

To determine whether silicone implantation exacerbates autoimmune disease in a murine experimental model of arthritis.

METHODS:

DBA/1 mice were implanted with silicone in the form of an elastomer, gel, or oil, and immunized with type II collagen. The influence of silicone implantation on collagen-induced arthritis and the immune response to type II collagen were determined by comparison against control mice receiving sham implantation. Adjuvant effects of silicone implantation were examined by measuring cytokine levels in implanted animals and assessing autoantibodies against proteins extracted from recovered silicone implants.

RESULTS:

No adverse influence of silicone implantation on the clinical aspects of collagen-induced arthritis was observed. Further, polydimethylsiloxane silicone oil failed to serve as an adjuvant in the immune or arthritogenic response to type II collagen in mice. Cytokine analysis indicated that tumor necrosis factor alpha levels were lower and interleukin-2 levels were higher in silicone-implanted mice. The development of arthritis increased protein binding to implanted elastomers and gel, and autoantibodies against silicone-bound proteins were present in sera from arthritic mice and absent in sera from nonarthritic mice.

CONCLUSION:

The data suggest that silicone implantation may result in autoantibodies against silicone-bound proteins, and the presence of arthritis may either provoke or increase the level of such autoantibodies. However, silicone implantation did not increase the incidence or severity of disease compared with sham-operated controls. Thus, it appears that autoantibodies against silicone-bound proteins may not have pathologic significance in this experimental model of arthritis.
Assuntos
Buscar no Google
Base de dados: MEDLINE Assunto principal: Artrite Experimental / Próteses e Implantes / Elastômeros de Silicone / Colágeno Tipo de estudo: Etiology_studies / Incidence_studies / Prognostic_studies Idioma: En Revista: Arthritis Rheum Ano de publicação: 1997 Tipo de documento: Article País de afiliação: Estados Unidos
Buscar no Google
Base de dados: MEDLINE Assunto principal: Artrite Experimental / Próteses e Implantes / Elastômeros de Silicone / Colágeno Tipo de estudo: Etiology_studies / Incidence_studies / Prognostic_studies Idioma: En Revista: Arthritis Rheum Ano de publicação: 1997 Tipo de documento: Article País de afiliação: Estados Unidos