Establishing orally self-administered cocaine as a reinforcer in rats using home-cage pre-exposure.
Prog Neuropsychopharmacol Biol Psychiatry
; 22(1): 229-39, 1998 Jan.
Article
em En
| MEDLINE
| ID: mdl-9533178
ABSTRACT
1. Rats were force-exposed to a cocaine + saccharin solution in their home cage water bottles for five days. They were then given 5 h home-cage access to both cocaine and cocaine-free solutions for 40 days. 2. The subjects consumed large doses of the cocaine solution despite the ad libitum availability of water. 3. The animals were then trained on a task consisting of operant bar pressing rewarded on an intermittent schedule with a liquid cocaine reinforcer. 4. All subjects performed the operant task and consumed doses of cocaine solution which are preferred over water in other paradigms. 5. Levels of responding were significantly reduced in three of four subjects when vehicle was substituted for liquid cocaine as the reward. 6. This demonstrates that orally self-administered cocaine can be used as a reinforcer in rats.
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Base de dados:
MEDLINE
Assunto principal:
Reforço Psicológico
/
Autoadministração
/
Cocaína
/
Condicionamento Operante
Idioma:
En
Revista:
Prog Neuropsychopharmacol Biol Psychiatry
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos