The effect of cyclooxygenase-2 inhibitor on experimental allergic neuritis.
Neuroreport
; 9(10): 2331-4, 1998 Jul 13.
Article
em En
| MEDLINE
| ID: mdl-9694223
ABSTRACT
We studied the effect of the cyclooxygenase (COX)-2 inhibitor nimesulide on experimental allergic neuritis (EAN). In rats fed with nimesulide starting on day 1 post inoculation, the clinical EAN score was significantly lower and the maximal clinical score was reduced compared with the control group. Even if given after the onset of clinical signs, the clinical score was reduced and improvement was faster than the control group. Nimesulide inhibited decreases in weight in the experimental group. The histopathological observations of the sciatic nerve showed a decreased incidence of degenerated nerve fibers in the experimental group. Although the exact mechanism of its efficacy is not clear, a COX-2 inhibitor may have potential as an additional therapeutic agent in human inflammatory neuropathies.
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Base de dados:
MEDLINE
Assunto principal:
Inibidores de Ciclo-Oxigenase
/
Prostaglandina-Endoperóxido Sintases
/
Isoenzimas
/
Neurite Autoimune Experimental
Idioma:
En
Revista:
Neuroreport
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Japão