Substituted tetrahydropyrrolo[2,1-b]oxazol-5(6H)-ones and tetrahydropyrrolo[2,1-b]thiazol-5(6H)-ones as hypoglycemic agents.
J Med Chem
; 41(23): 4556-66, 1998 Nov 05.
Article
em En
| MEDLINE
| ID: mdl-9804695
ABSTRACT
A series of substituted tetrahydropyrrolo[2,1-b]oxazol-5(6H)-ones and tetrahydropyrrolo[2,1-b]thiazol-5(6H)-ones was synthesized from amino alcohols or amino thiols and keto acids. A pharmacological model based on the results obtained with these compounds led to the synthesis and evaluation of a series of isoxazoles and other monocyclic compounds. These were evaluated for their ability to enhance glucose utilization in cultured L6 myocytes. The in vivo hypoglycemic efficacy and potency of these compounds were evaluated in a model of type 2 diabetes mellitus (non-insulin-dependent diabetes mellitus), the ob/ob mouse. 25a(2S) (SDZ PGU 693) was selected for further pharmacological studies.
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Base de dados:
MEDLINE
Assunto principal:
Oxazóis
/
Pirróis
/
Tiazóis
/
Hipoglicemiantes
Idioma:
En
Revista:
J Med Chem
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos