Thermotolerance in Saccharomyces cerevisiae: the Yin and Yang of trehalose.
Trends Biotechnol
; 16(11): 460-8, 1998 Nov.
Article
em En
| MEDLINE
| ID: mdl-9830154
ABSTRACT
Trehalose, a sugar produced by a wide variety of organisms, has long been known for its role in protecting certain organisms from desiccation. Recent work in yeast indicates that trehalose also promotes survival under conditions of extreme heat, by enabling proteins to retain their native conformation at elevated temperatures and suppressing the aggregation of denatured proteins. The latter property, however, seems to impair the recovery of cells from heat shock if they fail to degrade trehalose after the stress has passed. These multiple effects of trehalose on protein stability and folding suggest a host of promising applications.
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Base de dados:
MEDLINE
Medicinas Tradicionais:
Medicinas_tradicionales_de_asia
/
Medicina_china
Assunto principal:
Saccharomyces cerevisiae
/
Trealose
/
Proteínas Fúngicas
/
Resposta ao Choque Térmico
Idioma:
En
Revista:
Trends Biotechnol
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos