Magnesium supplementation alleviates premenstrual symptoms of fluid retention.
J Womens Health
; 7(9): 1157-65, 1998 Nov.
Article
em En
| MEDLINE
| ID: mdl-9861593
ABSTRACT
We investigated the effect of a daily supplement of 200 mg of magnesium (as MgO) for two menstrual cycles on the severity of premenstrual symptoms in a randomized, double-blind, placebo-controlled, crossover study. A daily supplement of 200 mg of Mg (as MgO) or placebo was administered for two menstrual cycles to each volunteer, who kept a daily record of her symptoms, using a 4-point scale in a menstrual diary of 22 items. Symptoms were grouped into six categories PMS-A (anxiety), PMS-C (craving), PMS-D (depression), PMS-H (hydration), PMS-O (other), and PMS-T (total overall symptoms). Urinary Mg output/24 hours was estimated from spot samples using the Mg/creatinine ratio. Analysis of variance for 38 women showed no effect of Mg supplementation compared with placebo in any category in the first month of supplementation. In the second month there was a greater reduction (p = 0.009) of symptoms of PMS-H (weight gain, swelling of extremities, breast tenderness, abdominal bloating) with Mg supplementation compared with placebo. Compliance to supplementation was confirmed by the greater mean estimated 24-hour urinary output of Mg (p = 0.013) during Mg supplementation (100.8 mg) compared with placebo (74.1 mg). A daily supplement of 200 mg of Mg (as MgO) reduced mild premenstrual symptoms of fluid retention in the second cycle of administration.
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Base de dados:
MEDLINE
Assunto principal:
Desequilíbrio Hidroeletrolítico
/
Síndrome Pré-Menstrual
/
Óxido de Magnésio
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
Idioma:
En
Revista:
J Womens Health
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Reino Unido