Cytotoxic constituents of Saussurea lappa.
Arch Pharm Res
; 21(2): 153-6, 1998 Apr.
Article
em En
| MEDLINE
| ID: mdl-9875423
ABSTRACT
The crude extract of Saussurea lappa displayed significant lethality to brine shrimp larvae. Investigation of the causative components by bioactivity-directed fractionation resulted in the isolation of three C17-polyene alcohols. Based on various nmr spectral data, these compounds were identified as shikokiols which had been previously isolated from Cirsium nipponicum and/or Centaurea aegyptica. These C17-polyene alcohols exhibited moderate cytotoxicities against the human tumor cell lines, A549, SK-OV-3, SK-MEL-2, XF498, and HCT15.
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Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
Assunto principal:
Plantas Medicinais
/
Antineoplásicos Fitogênicos
Idioma:
En
Revista:
Arch Pharm Res
Ano de publicação:
1998
Tipo de documento:
Article