Roles of Long Non-Coding RNAs on Tumorigenesis and Glioma Development
Brain Tumor Research and Treatment
; : 1-6, 2014.
Article
em En
| WPRIM
| ID: wpr-106238
Biblioteca responsável:
WPRO
ABSTRACT
More than 98% of eukaryotic transcriptomes are composed of non-coding RNAs with no functional protein-coding capacity. Those transcripts also include tens of thousands of long non-coding RNAs (lncRNAs) which are emerging as key elements of cellular homeostasis, essentially tumorigenesis steps. However, we are only beginning to understand the nature and extent of the involvement of lncRNAs on tumorigeneis. Here, we highlight recent progresses that have identified a myriad of molecular functions on tumorigenesis for several lncRNAs including metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), prostate cancer associated non-coding RNA 1 (PRNCR1), prostate cancer gene expression marker 1 (PCGEM1), H19, and homeobox transcript antisense intergenic RNA (HOTAIR), and several new lncRNAs for glioma development. Potential therapeutic approaches for the lncRNAs in various human diseases are also discussed.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Neoplasias da Próstata
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RNA
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Adenocarcinoma
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Expressão Gênica
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Genes Homeobox
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Estimulação Elétrica Nervosa Transcutânea
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RNA não Traduzido
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RNA Longo não Codificante
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Carcinogênese
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Glioma
Idioma:
En
Revista:
Brain Tumor Research and Treatment
Ano de publicação:
2014
Tipo de documento:
Article