Green Tea Polyphenols Attenuate High-Fat Diet-Induced Renal Oxidative Stress through SIRT3-Dependent Deacetylation / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 455-459, 2015.
Article
em En
| WPRIM
| ID: wpr-264562
Biblioteca responsável:
WPRO
ABSTRACT
Fifty male Wistar rats were fed a standard chow diet or a high-fat (HF) diet, and different concentrations of green tea polyphenols (GTPs) (0.8, 1.6, and 3.2 g/L) were administered in the drinking water. We found that the malondialdehyde (MDA) level in the HF diet group was significantly higher than that in the control (CON) group (P<0.05). Decreased peroxisome proliferator-activated receptor (PPAR)-α and sirtuin 3 (SIRT3) expression, and increased manganese superoxide dismutase (MnSOD) acetylation levels were also detected in the HF diet group (P<0.05). GTP treatment upregulated SIRT3 and PPARα expression, increased the pparα mRNA level, reduced the MnSOD acetylation level, and decreased MDA production in rats fed a HF diet (P<0.05). No significant differences in total renal MnSOD and PPAR-γ coactivator-1α (PGC1-α) expression were detected. The reduced oxidative stress detected in kidney tissues after GTP treatment was partly due to the higher SIRT3 expression, which was likely mediated by PPARα.
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Base de dados:
WPRIM
Assunto principal:
Farmacologia
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Acetilação
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Chá
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Regulação Enzimológica da Expressão Gênica
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Química
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Espécies Reativas de Oxigênio
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Ratos Wistar
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Estresse Oxidativo
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Sirtuína 3
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Polifenóis
Idioma:
En
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2015
Tipo de documento:
Article