Protective effect of Rheum tanguticum polysaccharides (RTP) on traumatic brain injury in rats / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate protective effects of Rheum tanguticum polysaccharides (RTP) on traumatic brain injury (TBI) in rats.</p><p><b>METHOD</b>The polysaccharides (RTP) were extracted from Tanguficum Maxim. 120 rats were divided into 15 groups, with 8 rats in each group. RTP at 100, 200 and 400 mg x kg(-1) were administrated orally once a day for five days, and model of brain injury was made by dropping weight method.</p><p><b>RESULT</b>RTP reduced water content and malondialdehyde (MDA) levels, and increased total SOD activity and Na+-K+ ATPase activity after injuried.</p><p><b>CONCLUSION</b>The polysaccharides may be one of the effective comptents in Rheum tanguticum, showing significant neuroprotective effects.</p>