Phytoestrogens in application prospect of treatment of myocardial ischemia/reperfusion injury / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 3132-3136, 2015.
Article
em Zh
| WPRIM
| ID: wpr-304845
Biblioteca responsável:
WPRO
ABSTRACT
Reperfusion is the most effective treatment for acute myocardial infarction, markedly reducing mortality and morbidity. Reperfusion however induces necrotic and apoptotic damages to cardiomyocytes, that were viable prior to reperfusion, a process called myocardial ischemia/reperfusion injury(MI/RI). Over the past 30 years, hundreds of experimental interventions (both pharmacologic and nonpharmacologic) have been reported to protect the ischemic myocardium in experimental animals; however, with the exception of early reperfusion, none has been translated into clinical practice. The population-based survey assessed men have about twice the total incidence of morbidity and mortality of women, and the sex gap in morbidity tends to diminish after age 45 years. So hormone replacement therapy (HRT) is given to treat the MI/RI, and lots of studies shows that the side effect is greater for estrogen, compared with phyestrogen. In this article, we review the important pathogenesis of myocardial ischemia reperfusion injury, the prevention and limitations of HRT. And we highlight the mechanism of phyestrogens treatment the MI/RI in experiment. The aim is to provide the theoretically new way of develop the safe and effective products for the researchers.
Texto completo:
1
Base de dados:
WPRIM
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
Assunto principal:
Extratos Vegetais
/
Traumatismo por Reperfusão Miocárdica
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Isquemia Miocárdica
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Fitoestrógenos
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Tratamento Farmacológico
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2015
Tipo de documento:
Article