Progress of berberine for treatment of type 2 diabetes / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1374-1378, 2014.
Article
em Zh
| WPRIM
| ID: wpr-321307
Biblioteca responsável:
WPRO
ABSTRACT
Berberine is the major component of Coptidis Rhizoma and it has been used as anti-infection, anti-inflammation drug for gastrointestinal diseases. In recent years, evidence showed that it could regulate glucose and lipid metabolism. Moreover, its activity had been tested by clinical trials and animal researches. The mechanisms of berberine in diabetes include: improving the function of beta-cell; prompting insulin secretion and islets regeneration, lowing lipid level, regulating glucose and lipid metabolic by influence transcriptional factors expression such as PPARgamma, C/EBPalpha, SREBP-1c, LXR, having the activities of anti-oxidation and inhibiting reductase to repress oxidative stress state and regulate metabolic signal pathway. Although numbers of data supported that berberine could improving insulin resistance by clinical trials and animal studies, the large scale, multicenter clinical trials are needed to evaluate the effects of berberine for diabetes and its complications in the time of evidence-based medicine.
Texto completo:
1
Base de dados:
WPRIM
Métodos Terapêuticos e Terapias MTCI:
Plantas_medicinales
Assunto principal:
Berberina
/
Usos Terapêuticos
/
Diabetes Mellitus Tipo 2
/
Tratamento Farmacológico
/
Metabolismo dos Lipídeos
/
Genética
/
Glucose
/
Hipoglicemiantes
/
Insulina
/
Metabolismo
Tipo de estudo:
Clinical_trials
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2014
Tipo de documento:
Article