The effects of nicotine on bone calcium and phosphorus content and alkaline phosphatase activity in different part of rat / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 225-231, 2013.
Article
em Zh
| WPRIM
| ID: wpr-336352
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the effects of nicotine on the bone calcium and phosphorus content and alkaline phosphatase (ALP) activity in rat alveolar bone and mandible.</p><p><b>METHODS</b>Twenty health male Wistar rats of five weeks of age were randomly assigned to two groups and received daily intraperitoneal injections for three months as follows Saline solution for control group, nicotine 0.73 mg.kg-l.d-1 for experimental group. The bone calcium phosphorus content were detected by concentrated acid digestion method and the ALP activity was examined by improved Reddi method.</p><p><b>RESULTS</b>Compared to the control group, bone calcium and phosphorus content was lower in the experimental group (P<0.05), ALP activity had no statistical significance(P>0.05). Bone calcium phosphorus and ALP activity in different parts had no statistical significance (P>0.05).</p><p><b>CONCLUSION</b>The nicotine reduces calcium phosphorus deposition of jaw bone, but has no obvious influence to ALP activity.</p>
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Base de dados:
WPRIM
Assunto principal:
Fósforo
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Osso e Ossos
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Cálcio
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Ratos Wistar
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Fosfatase Alcalina
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Nicotina
Idioma:
Zh
Revista:
West China Journal of Stomatology
Ano de publicação:
2013
Tipo de documento:
Article