Effect of aralosides to contraction function and calcium transient of ischemia/reperfusion myocardial cells / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2403-2407, 2015.
Article
em Zh
| WPRIM
| ID: wpr-337921
Biblioteca responsável:
WPRO
ABSTRACT
To discuss the protective effect of aralosides (AS) on I/R-induced rat myocardial injury. The adult rat ventricular myocyte ischemia model was established through perfusion with sodium lactate perfusate and reperfusion with Ca(2+) -containing Tyrode's solution simulation. The cell contraction and ion concentration synchronization determination system was applied to detect the effect of AS on single I/R cell contraction and Ca2+ transients. According to the findings, AS could increase resting sarcomere length, contraction amplitude, ± dL/dt(max), calcium transient amplitude and speed of post-reperfusion myocardial cells (P < 0.05, P < 0.01), and decrease in time for achieving 90.0% of maximum relaxation, time for achieving peak value, resting calcium ratio, contraction period [Ca2+] i, time for achieving 50.0% of maximum relaxation and attenuation rate of intracellular calcium transient (P < 0.05, P < 0.01). Therefore, it is suggested that AS improved the post-reperfusion cell contraction and injury of calcium homeostasis.
Texto completo:
1
Base de dados:
WPRIM
Medicinas Tradicionais:
Medicinas_tradicionales_de_asia
/
Medicina_china
Assunto principal:
Fisiologia
/
Saponinas
/
Cirurgia Geral
/
Transporte Biológico
/
Medicamentos de Ervas Chinesas
/
Reperfusão Miocárdica
/
Química
/
Cálcio
/
Ratos Sprague-Dawley
/
Isquemia Miocárdica
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2015
Tipo de documento:
Article