Effects of individualized nutritional therapy on nutritional status of patients in perioperative period of digestive system operation / 第二军医大学学报

ABSTRACT

Objective: To explore the effect of individualized nutritional therapy on nutritional status of patients with nutritional risk in the perioperative period of the digestive system operation. Methods: This study was a prospective, randomized, controlled clinical trial. Patients undergoing elective digestive surgery were screened for nutritional risk. And 231 patients who had nutritional risk and signed informed consent were randomized into study group (n=115) and control group (n = 116). Individualized and non-individualized nutritional treatments were given for 15 d (5 d before surgery and 9 d after surgery) in two groups. The baseline data were collected. At admission, and on day 5, 9 and 15 after nutrition treatment, venous blood samples were collected, and relevant indicators, such as the body mass index (BMI), serum total protein, albumin, prealbumin, blood glucose, total cholesterol, triglyceride, lymphocyte count and white blood cell count, were measured. Results: At the end of the trial, 217 patients were collected from the study group (n=112) and control group (n=105). Fourteen patients (6.1%) withdrew from the study. In the study group, the levels of serum total protein, albumin and prealbumin were frst increased, then decreased, and then increased again (P0.05). Serum total protein and albumin levels were significantly higher in the study group than those in the control group (P0.05). The duration of nutrition treatment was not related to nutritional or immune indexes (P>0.05). Conclusion: Individualized nutritional therapy can improve the nutritional status of patients with nutritional risks in the perioperative period of the digestive system operation.