Research progress on mechanism and treatment of osteoporosis by intestinal flora / 中国药理学通报

ABSTRACT

The intestinal flora is a kind of microorganisms colonized in the human gastrointestinal tract and is closely related to human health. A large number of studies have found that the intestinal flora is closely related to the bone health of the body. The mechanism of intestinal flora affecting osteoporosis may be through its own metabolites, affecting host metabolism, regulating intestinal barrier function and immune system, and affecting drug metabolism. The above-mentioned mechanisms affecting osteoporosis are discussed, and examples of targeting intestinal preparations for osteoporosis are listed, which provide new ways for the study of the mechanism of action of drugs, new solutions for solving osteoporosis caused by various causes, and new ideas for the research and development of new drugs.