Antiarrhythmic active components in traditional Chinese medicine acting on potassium channels / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1792-1799, 2023.
Article
em Zh
| WPRIM
| ID: wpr-981396
Biblioteca responsável:
WPRO
ABSTRACT
Arrhythmia is an external manifestation of cardiac electrophysiological disorder. It exists in healthy people and patients with various heart diseases, which is often associated with other cardiovascular diseases. The contraction and diastole of myocardium are inseparable from the movement of ions. There are many ion channels in the membrane and organelle membrane of myocardium. The dynamic balance of myocardial ions is vital in maintaining myocardial electrical homeostasis. Potassium ion channels that have a complex variety and a wide distribution are involved in the whole process of resting potential and action potential of cardiomyocytes. Potassium ion channels play a vital role in maintaining normal electrophysiological activity of myocardium and is one of the pathogenesis of arrhythmia. Traditional Chinese medicine(TCM)has unique advantages in treating arrhythmia for its complex active components and diverse targets. A large number of TCM preparations have definite effect on treating arrhythmia-related diseases, whose antiarrhythmic mechanism may be related to the effect on potassium channel. This article mainly reviewed the relevant studies on the active components in TCM acting on different potassium channels to provide references for clinical drug use and development.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Medicinas Tradicionais:
Medicinas_tradicionales_de_asia
/
Medicina_china
Assunto principal:
Arritmias Cardíacas
/
Canais de Potássio
/
Cardiopatias
/
Íons
/
Medicina Tradicional Chinesa
/
Antiarrítmicos
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2023
Tipo de documento:
Article