1.
Bioorg Med Chem Lett
; 25(1): 48-52, 2015 Jan 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-25435147
RESUMEN
We have identified a new series of N-aryl azacycles as sodium channel blockers, which showed good potency on Nav1.7 in FLIPR-based and electrophysiological functional assays. Analogs from this series possessed selectivity over hERG, reasonable oral exposure in rat PK studies and are predicted to have limited CNS penetration.