RESUMEN
Current treatment of chronic wounds has been critically limited by various factors, including bacterial infection, biofilm formation, impaired angiogenesis, and prolonged inflammation. Addressing these challenges, we developed a multifunctional wound dressing-based three-pronged approach for accelerating wound healing. The multifunctional wound dressing, composed of nanofibers, functional nanoparticles, natural biopolymers, and selected protein and peptide, can target multiple endogenous repair mechanisms and represents a promising alternative to current wound healing products.
Asunto(s)
Anexina A1/administración & dosificación , Antiinflamatorios/administración & dosificación , Vendajes , Diabetes Mellitus Experimental/complicaciones , Proteínas Relacionadas con la Folistatina/administración & dosificación , Péptidos/administración & dosificación , Infecciones Estafilocócicas/complicaciones , Infecciones Estafilocócicas/tratamiento farmacológico , Staphylococcus aureus/efectos de los fármacos , Herida Quirúrgica/complicaciones , Herida Quirúrgica/tratamiento farmacológico , Cicatrización de Heridas/efectos de los fármacos , Infección de Heridas/complicaciones , Infección de Heridas/tratamiento farmacológico , Células 3T3 , Animales , Materiales Biocompatibles/administración & dosificación , Biopolímeros/química , Supervivencia Celular/efectos de los fármacos , Diabetes Mellitus Experimental/inducido químicamente , Células HaCaT , Humanos , Nanopartículas Magnéticas de Óxido de Hierro/química , Masculino , Ensayo de Materiales/métodos , Ratones , Nanofibras/química , Ratas , Ratas Wistar , Infecciones Estafilocócicas/microbiología , Resultado del Tratamiento , Infección de Heridas/microbiologíaRESUMEN
New N-monosubstituted diaminomaleonitrile-based azo-azomethine dyes have been synthesized in order to develop colorimetric sensors for detection of biologically important anions in aqueous media. Importantly, the reported sensor decorated with strong electron-withdrawing group can detect inorganic fluoride in water even at 0.037 ppm level, which is lower than WHO permissible level (below 1 ppm). Successfully, the prepared dyes were used for qualitative and quantitative detection of inorganic fluoride in toothpaste and mouthwash. The anion recognition mechanism was also investigated by detailed UV-Vis and (1)H NMR experiments. The detailed (1)H NMR experiments corroborated that anion recognition is based on the deprotonation phenomenon.