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A large proportion of surgical residents that are applying to surgical critical care(SCC) and acute care surgery(ACS) fellowships are describing cases where they cared for patients with injuries from penetrating trauma in their personal statements. These cases appear to have served as an inspiration for their fellowship and career decision. However a substantial percentage of training in these fellowships occurs in the ICU and there also have been steadily decreasing rates of operative penetrating trauma throughout the United States over the last several decades. This incongruity is explored and suggestions are made for formal mentorship to occur between surgical residents interested in further training in SCC and ACS and attendings practicing within these fields.
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Splenic rupture, a critical surgical emergency involving the tearing of the spleen's capsule and the ensuing internal bleeding, primarily results from abdominal trauma or underlying medical conditions affecting the spleen. A 71-year-old male with hypertension and hyperlipidemia suffered a mechanical fall, leading to his presentation in the emergency department. Despite a stable initial condition and discharge, he returned the following day with dizziness and severe anemia. Subsequent diagnostics revealed a ruptured spleen, necessitating immediate surgical intervention. This case emphasizes traumatic and atraumatic causes of splenic rupture, with older adults, anticoagulant users, and viral illnesses accentuating vulnerability. Physical exam findings might be absent, highlighting the importance of considering splenic rupture in cases of unexplained hemodynamic instability. In this instance, a combination of trauma, a possible history of anticoagulation use, and a recent viral illness contributed to the patient's splenic rupture. The case underscores the need to retain a high index of suspicion for splenic rupture even without obvious physical findings, advocating for diligent evaluation of abnormal vital signs.
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The perception and behavior of the public is key in reducing Traffic-related air pollution health burdens which has become an increasingly alarming problem in many cities across the globe. The study assessed the perception of the public about vehicle traffic emissions and the health hazard associated with them in Lagos, Nigeria using structured questionnaires. Multivariate statistical analysis and structural equation modeling were performed to determine the factors that were associated with the participant's perception of traffic air pollution and the health risks it presents. The findings revealed the majority (78.9%) of the respondents were aware of the haze air pollution from vehicles and its adverse effects on health. The regression model showed a significant relationship between age, education status, employment status, road proximity, vehicle ownership and air pollution awareness (P < 0.05). However, the structural equation model SEM revealed that age, gender, marital status, education, employment status, and road proximity showed statistical significance (p < 0.05) and indicated a linear relationship to vehicular emissions perception. The findings suggest the need to increase public education for all ages and especially for roadside residents on the effects of prolonged exposure and long-term effects of transport-related air pollution and associated risk. The result is applicable in many developing cities, especially in Sub-Saharan Africa.
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INTRODUCTION: Surgical stabilization of rib fractures (SSRF) improves functional outcomes compared to controls, partly due to reduction in pain. We investigated the impact of early SSRF on pulmonary complications, mortality, and length of stay compared to non-operative analgesia with epidural analgesia (EA). METHODS: Retrospective cohort study of the Trauma Quality Improvement Program (TQIP) 2017 dataset for adults with rib fractures, excluding those with traumatic brain injury or death within twenty-four hours. Early SSRF and EA occurred within 72 h, and we excluded those who received both or neither intervention. Our primary outcome was a composite of pulmonary complications including acute respiratory distress syndrome (ARDS) or ventilator-associated pneumonia (VAP). Additional outcomes included unplanned endotracheal intubation, in-hospital mortality, and hospital and intensive care unit (ICU) length of stay (LOS) for those surviving to discharge. Multiple logistic and linear regressions were controlled for variables including age, sex, flail chest (FC), injury severity, additional procedures, and medical comorbidities. RESULTS: We included 1,024 and 1,109 patients undergoing early SSRF and EA, respectively. SSRF patients were more severely injured with higher rates of FC (42.8 vs 13.3%, p<0.001), Injury Severity Score (ISS) > 16 (56.9 vs 36.1%, p<0.001), and Abbreviated Injury Scale (AIS) Thorax > 3 (33.3 vs 12.2%, p<0.001). Overall, 49 (2.3%) of patients developed ARDS or VAP, 111 (5.2%) required unplanned intubation, and 58 (2.7%) expired prior to discharge. On multivariable analysis, SSRF was not associated with the primary composite outcome (OR: 1.65, 95%CI: 0.85-3.21). Early SSRF significantly predicted decreased risk of unplanned intubation (OR:0.59, 95%CI: 0.38-0.92) compared with early EA alone, however, was not a significant predictor of in-hospital mortality (OR: 1.27, 95%CI: 0.68-2.39). SSRF was associated with significantly longer hospital (Exp(ß): 1.06, 95%CI: 1.00-1.12, p = 0.047) and ICU LOS (Exp(ß): 1.17, 95%CI: 1.08-1.27, p<0.001). CONCLUSIONS: Aside from unplanned intubation, we observed no statistically significant difference in the adjusted odds of in-hospital pulmonary morbidity or mortality for patients undergoing early SSRF compared with early EA. Chest wall injury patients may benefit from referral to trauma centers where both interventions are available and appropriate surgical candidates may receive timely intervention.
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Analgesia Epidural , Tórax Paradójico , Síndrome de Dificultad Respiratoria , Fracturas de las Costillas , Adulto , Humanos , Fracturas de las Costillas/complicaciones , Fracturas de las Costillas/cirugía , Estudios Retrospectivos , Tórax Paradójico/cirugía , Tiempo de Internación , HospitalesRESUMEN
BACKGROUND: Speed calming interventions have been employed globally as a road safety measure to curb outcomes of RTCs such as injuries and deaths. In Ghana, few studies have reported on the effect of speed calming measures on the severity of road traffic injuries. This study examined the effect of speed humps on the severity of injuries during RTCs on trunk roads passing through towns in Ghana from 2011 to 2020. METHODS: The study employed a quasi-experimental before-and-after study with controls design to answer the research questions. The study used both primary and secondary sources of data. Univariable and multivariable ordered logistic regression was used to examine the effect of speed humps on the severity of injuries during RTCs. RESULTS: The mean height, length and spacing of the speed humps were 10.9 cm, 7.67 m and 207.17 m, respectively. Fatal/serious/minor injuries were 35% higher at the intervention than the control settlements prior to installation of speed humps though not significant (adjusted OR (aOR)=1.35, 95% CI 0.85 to 2.14). A significant change in injury severity occurred after the installation of the speed hump devices. There was a reduction of 77% in fatal/serious/minor injuries at the intervention towns compared with the control towns (aOR=0.23, 95% CI 0.11 to 0.47). CONCLUSION: The findings present evidence suggesting that speed hump is an effective road safety measure in reducing the severity of road traffic injuries on trunk roads.
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Accidentes de Tránsito , Humanos , Accidentes de Tránsito/prevención & control , Ciudades , Ghana/epidemiología , Modelos Logísticos , Recolección de DatosRESUMEN
BACKGROUND: We hypothesized that implementation of new ultra-restrictive transfusion protocol in adult surgical intensive care units (SICU) was safe and feasible during pandemic-associated shortage crises. METHODS: Retrospective analysis two months pre- and post-implementation of ultra-restrictive transfusion protocol in March 2020 with hemoglobin cutoff of 6 g/dL (6.5 g/dL if ≥ 65 years old) for patients without COVID, active bleeding, or myocardial ischemia. RESULTS: We identified 16/93 and 27/168 patients PRE and POST meeting standard transfusion threshold (7 g/dL); within POST, 12 patients met ultra-restrictive cutoffs. There was no significant difference between PRE and POST in the rate of mortality, ischemic complications, or the number of transfusions per patient, however, the overall incidence of transfusion was lower in the POST group (7.1 vs 17.2%, p = 0.02). Patients received a mean (SD) of 4(3.8) and 2.4(1.5) PRBC transfusions pre- and post-implementation. Odds ratio of mortality in POST group was 0.62 (95%CI: 0.08-5.12) adjusted for age, sex, and SOFA score. CONCLUSIONS: Implementation of an ultra-restrictive transfusion protocol was feasible and effective as a blood- preservation strategy.
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Transfusión de Eritrocitos , Adulto , Transfusión de Eritrocitos/métodos , Estudios de Factibilidad , Hemoglobinas/análisis , Humanos , Unidades de Cuidados Intensivos , Estudios RetrospectivosRESUMEN
Introduction: Approaches to COVID-19 mitigation can be more efficiently delivered with a more detailed understanding of where the severe cases occur. Our objective was to assess which demographic, housing and neighborhood characteristics were independently and collectively associated with differing rates of severe COVID-19. Methods: A cohort of patients with SARS-CoV-2 in a single health system from March 1, 2020 to February 15, 2021 was reviewed to determine whether demographic, housing, or neighborhood characteristics are associated with higher rates of severe COVID-19 infections and to create a novel scoring index. Characteristics included proportion of multifamily homes, essential workers, and ages of the homes within neighborhoods. Results: There were 735 COVID-19 ICU admissions in the study interval which accounted for 61 percent of the state's ICU admissions for COVID-19. Compared to the general population of the state those admitted to the ICU with COVID-19 were disproportionately older, male sex, and were more often Black, Indigenous, People of Color. Patients disproportionately resided in neighborhoods with three plus unit multifamily homes, homes built before 1940, homes with more than one person to a room, homes of lower average value, and in neighborhoods with a greater proportion of essential workers. From this our COVID-19 Neighborhood Index value was comparatively higher for the ICU patients (61.1) relative to the population of Rhode Island (49.4). Conclusion: COVID-19-related ICU admissions are highly related to demographic, housing and neighborhood-level factors. This may guide more nuanced and targeted vaccine distribution plans and public health measures for future pandemics.
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The effects of plants on insects are not completely clear due to potential covariation of weather or location affecting both assemblages. To address this question, plant and insect assemblages were described during summer 2019 and 2020 in two different forest habitats of northern Lower Michigan. The first habitat was a hardwood forest typical of secondary succession in the region. The second was a hydric forest located ~20 m from the hardwood forest which developed after lake sediment was deposited into a 10-ha area in the early 2000s. Reflecting this sediment deposition, soil of the hydric forest had higher water content and organic matter, and was dominated by the plant genera Solidago (Asterales: Asteraceae), Rubus (Rosales: Rosaceae), and Salix (Malpighiales: Salicaceae). In contrast, the hardwood forest had greater inorganic sediment and was dominated by Pteridium (Polypodiales: Dennstaedtiaceae), Carex (Poales: Cyperaceae), and Acer. Nearly 140,000 insect specimens were sampled using pitfall trapping, sweep netting, flight intercept trapping, ultraviolet light trapping, and yellow and blue pan trapping. The first three methods each sampled a unique insect assemblage, whereas the last three overlapped in taxa sampled. Insect assemblages of the two forests were distinct from each other using any of the six methods, with abundance of Pteridium and Salix (Sapindales: Sapindaceae) generally associating with changes in insect composition. A total of 41 insect taxa indicated the hydric forest and 14 indicated the hardwood forest. Insect richness increased with that of plants. These results demonstrate that differences in soil composition and plant assemblages associate with differences in forest insect assemblages, even of forests in very close proximity.
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Ecosistema , Bosques , Animales , Insectos , Michigan , Plantas , Suelo , Estados UnidosRESUMEN
We exploit the effect of light-induced atomic desorption to produce high atomic densities (nâ«k^{3}) in a rubidium vapor cell. An intense off-resonant laser is pulsed for roughly one nanosecond on a micrometer-sized sapphire-coated cell, which results in the desorption of atomic clouds from both internal surfaces. We probe the transient atomic density evolution by time-resolved absorption spectroscopy. With a temporal resolution of ≈ 1 ns, we measure the broadening and line shift of the atomic resonances. Both broadening and line shift are attributed to dipole-dipole interactions. This fast switching of the atomic density and dipolar interactions could be the basis for future quantum devices based on the excitation blockade.
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BACKGROUND: Percutaneous endoscopic gastrostomy (PEG) tubes are placed by gastroenterologists (GI) and surgeons throughout the country. At Rhode Island Hospital, before July of 2017, all PEGs were placed by GI. In July of 2017, in response to a growing need for PEGs, acute care surgeons (ACS) also began performing PEGs at the bedside in ICUs. The purpose of this study was to review and compare outcomes of PEG tubes placed by ACS and GI. METHODS: Retrospective chart review of patients who received a PEG placed by ACS or GI at the bedside in any ICU from December 2016 to September 2019. Charts were reviewed for the following outcomes: Success rates of placing PEG, duration of procedure, major complications, and death. Secondary outcomes included discharge disposition, and rates of comfort measures only after PEG. RESULTS: In 2017, 75% of PEGs were placed by GI and 25% surgery. In 2018, 47% were placed by GI and 53% by surgery. In 2019, 33% were placed by GI and 67% by surgery. There was no significant difference in success rates between surgery (146/156 93.6%) and GI (173/185 93.5%) (p 0.97). On average, GI performed the procedure faster than surgery [Median 10 (7-16) min vs 16 (13-21) mins, respectively, p < 0.001]. There were no significant differences between groups in any of the PEG outcomes or complications investigated. CONCLUSION: Bedside PEG tube placement appears to be a safe procedure in the ICU population. GI and Surgery had nearly identical success rates in placing PEGs. GI performed the procedure faster than surgery. There were no significant differences in the reviewed patient outcomes or complications between PEGs placed by ACS or GI. Of note, when a complication occurred, ACS PEG patients typically were managed in the OR while GI tended to re-PEG patients highlighting a potential difference in management that should be further investigated.
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Gastroenterología , Cirujanos , Humanos , Estudios Retrospectivos , Complicaciones Posoperatorias/epidemiología , Complicaciones Posoperatorias/etiología , Gastrostomía/métodosRESUMEN
BACKGROUND: At many trauma centers in the United States, one acute care surgeon is responsible for overnight coverage of both the emergency general surgery (EGS) and trauma services. The impact of this scheduling phenomenon on the quality and safety of trauma care has not been studied. METHODS: Overnight (12:00 AM to 7:00 AM) trauma admissions to an academic Level 1 trauma center from 2013-2015 were studied after the institution adopted this scheduling phenomenon. Admissions were divided into two groups based on whether the admitting surgeon covered only the trauma service, or both the trauma and EGS services ("multi-service coverage"). Four major outcomes (e.g., mortality and complications), six quality metrics (e.g., time to first OR visit and unplanned transfers to the ICU), and procedural utilization patterns were compared. RESULTS: A total of 1046 admissions were included. There were no differences in any major outcomes between the two exposure groups, including any National Trauma Data Bank-defined complication (OR 1.1, 95% CI 0.8-1.5, P= 0.5). Quality metrics dependent on the admitting surgeon remained unchanged, including attending presence at the highest-level trauma activations within 15 min of arrival (93% versus 86%, P= 0.07) and time to urgent operative intervention (68 min versus 82 min, P= 0.9). There were no differences in the number of laboratory and imaging studies (4.1 versus 4.1, P= 0.9) or bedside interventions (1.8 versus 2.1, P= 0.4) performed per patient by the admitting surgeon. Multivariate logistic regression did not identify multi-service coverage as an independent risk factor for adverse patient outcomes or quality metrics. CONCLUSIONS: Trauma admissions under a surgeon covering multiple services simultaneously had similar outcomes, quality metrics, and procedural utilization patterns compared to trauma admissions under surgeons covering only the trauma service. Despite concerns that multiple-service coverage may overburden one acute care surgeon, time-dependent quality metrics and studies done during the initial workup of trauma patients remained unchanged. These findings suggest that simultaneous trauma and EGS service coverage by one acute care surgeon does not adversely impact trauma patient care.
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Cirujanos , Centros Traumatológicos , Cuidados Críticos , Humanos , Estudios Retrospectivos , Estados UnidosRESUMEN
BACKGROUND: Injured patients benefit from direct transport to a trauma center; however, it is unknown whether patients with traumatic out-of-hospital cardiac arrest (OHCA) benefit from initial resuscitation at the nearest emergency department (ED) if a trauma center is farther away. We hypothesized that patients with traumatic OHCA transported directly to a trauma center have less in-hospital mortality after initial resuscitation compared to those transferred from non-trauma centers. METHODS: We examined patients presenting with traumatic OHCA within our institutional trauma registry and the National Trauma Data Bank (NTDB) and excluded patients with ED mortality. Our primary outcome was all-cause mortality during index hospitalization; multiple logistic regression controlled for age, sex, injury severity score, mechanism of injury, signs of life, emergency surgery, and level I trauma center designation. RESULTS: We identified 271 and 1,138 adult patients with traumatic OHCA in our registry and the NTDB; 28% and 16% were transferred from another facility, respectively. Following initial resuscitation, patients transferred to a trauma center had higher in-hospital mortality than those transported directly in both our local and national cohorts (aOR: 2.27, 95%CI: 1.03-4.98, and aOR: 2.66, 95%CI: 1.35 - 5.26, respectively). DISCUSSION: Patients with traumatic OHCA transported directly to a trauma center may have increased survival to discharge compared to those transferred from another facility, even accounting for initial resuscitation. Further investigation should examine the impact of both physiologic and logistic factors including distance to trauma center, traffic, and weather patterns that may impact prehospital decision-making and destination selection.
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Reanimación Cardiopulmonar , Servicios Médicos de Urgencia , Paro Cardíaco Extrahospitalario , Adulto , Hospitales , Humanos , Paro Cardíaco Extrahospitalario/terapia , Sistema de Registros , Estudios RetrospectivosRESUMEN
We demonstrate a collectively encoded qubit based on a single Rydberg excitation stored in an ensemble of N entangled atoms. Qubit rotations are performed by applying microwave fields that drive excitations between Rydberg states. Coherent readout is performed by mapping the excitation into a single photon. Ramsey interferometry is used to probe the coherence of the qubit, as well as to test the robustness to external perturbations. We show that qubit coherence is preserved even as we lose atoms from the polariton mode, preserving Ramsey fringe visibility. We show that dephasing due to electric field noise scales as the fourth power of field amplitude. These results show that robust quantum information processing can be achieved via collective encoding using Rydberg polaritons, and hence this system could provide an attractive alternative coding strategy for quantum computation and networking.
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BACKGROUND: Early identification of traumatic brain injury (TBI) with head CT HCT should expedite operative decision-making and improve outcome. We aimed to determine whether an early HCT protocol in TBI patients would improve outcome. METHODS: A multidisciplinary protocol to obtain an HCT within 30 minutes from arrival for patients with GCS ≤ 13 was instituted on 1/1/2015. Our trauma registry was queried for patients evaluated between 3/2012 and 12/2015. Outcomes included compliance with protocol and in-hospital mortality. RESULTS: 346 patients presented with GCS ≤ 13. Patients PRE- (n=264) and POST-protocol (n=82) were similar in demographic and physiologic characteristics. Time to HCT was lower (35 vs. 77 min; p<0.001). POST-protocol had lower odds of mortality (OR 0.65, 95% CI 0.43-0.99) adjusting for age, gender, ISS and GCS. CONCLUSION: Implementing a protocol of early HCT for TBI optimized performance of the trauma team. Time to HCT could serve as a quality metric in TBI.
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Lesiones Traumáticas del Encéfalo , Mejoramiento de la Calidad , Factores de Edad , Lesiones Traumáticas del Encéfalo/diagnóstico por imagen , Mortalidad Hospitalaria , Humanos , Tomografía Computarizada por Rayos XRESUMEN
The study seeks to identify bicycle ownership and ridership and gain insights into how demographics, perceptions and experiences of respondents influenced the status of cycling in Tamale Metropolis. Earlier studies have focused on examining the determinants of utility cycling among adults in the same metropolis, but this study assesses cycling from a broader perspective in terms of demographics, barriers, and promotional strategies. A cross-sectional survey was carried out with 500 semi-structured questionnaires through mainly a face-to-face approach. Five trained survey assistants administered the questionnaires within demarcated zones in the metropolis and tracked participants by geographic information system. Binary logistic regression, chi-squared test and descriptive statistics were employed in the analysis of the data. Out of the 439 valid questionnaires, bicycle ownership and ridership were 56% and 78% respectively. Gender and occupation were significant in owning and riding bicycles, where p < 0.05. Males and the non-income earners (i.e., students, apprentices and unemployed) were more likely to ride and own bicycles. Cycling was prevalent among low-income individuals and in households where bicycles were available. The major motivation of bicycle riders was affordability. Age was statistically insignificant to owning or riding bicycles since every age group cycled as much. Despite the existing infrastructure provision for cycling and its associated benefits, there is a latent desire to shift from bicycles by 85% of the riders. A chi-square test conducted revealed that the desire to shift from bicycle use was independent of one's gender, age and occupation, but associated with bicycle ownership. Moreover, speed, fatigue endured in riding and inadequate infrastructure were mentioned as part of the factors that discourage cycling. This study, therefore, recommends government interventions such as a reduction in bicycle cost, and the introduction of electric bicycles to meet the respondents' transport needs of speed and travelling with less fatigue.
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BACKGROUND: The American College of Surgeons Resources for Optimal Care of the Injured Patient recommends using hypotension, defined as systolic blood pressure ≤90 mm Hg, as an indicator of a full team trauma activation. We hypothesized that an elevated shock index (SI) predicts significant traumatic injuries better than hypotension alone. METHODS: This is a retrospective cohort study analyzing full team trauma activations between February 2018 and January 2020, excluding transfers and those who had missing values for prehospital blood pressure or heart rate. We reviewed patients' demographics, prehospital and emergency department vitals, injury pattern, need for operation, and clinical outcomes. The primary outcome was rate of significant injury defined as identified injured liver, spleen, or kidney, pelvis fracture, long bone fracture, significant extremity soft tissue damage, hemothorax, or pneumothorax. RESULTS: Among 544 patients, 82 (15.1%) had prehospital hypotension and 492 had normal blood pressure. Of the patients with prehospital hypotension, 34 (41.5%) had a significant injury. There was no difference in age, gender, medical history, or injury pattern between the two groups. There was no difference between the two groups in rate of serious injury (41.5% vs. 46.1%, NS), need for emergent operation (31.7% vs. 28.1%, NS) or death (20.7% vs. 18.8%, NS). On the other hand, SI ≥1 was associated with increased rate of serious injury (54.6% vs. 43.4%, p=0.04). On a logistic regression analysis, prehospital hypotension was not associated with significant injury or need for emergent operation (OR 0.83, 95% CI 0.51 to 1.33 and OR 1.32, 95% CI 0.79 to 2.25, respectively). SI ≥1 was associated with both increased odds of significant injury and need for emergent operation (OR 1.57, 95% CI 1.01 to 2.44 and OR 1.64, 95% CI 1.01 to 2.66). DISCUSSION: SI was a better indicator and could replace hypotension to better categorize and triage patients in need of higher level of care. LEVEL OF EVIDENCE: Prognostic and epidemiologic, level III.
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OBJECTIVES: The Cribari Matrix Method (CMM) is the current standard to identify over/undertriage but requires manual trauma triage reviews to address its inadequacies. The Standardized Triage Assessment Tool (STAT) partially emulates triage review by combining CMM with the Need For Trauma Intervention, an indicator of major trauma. This study aimed to validate STAT in a multicenter sample. METHODS: Thirty-eight adult and pediatric US trauma centers submitted data for 97,282 encounters. Mixed models estimated the effects of overtriage and undertriage versus appropriate triage on the odds of complication, odds of discharge to a continuing care facility, and differences in length of stay for both CMM and STAT. Significance was assessed at p <0.005. RESULTS: Overtriage (53.49% vs. 30.79%) and undertriage (17.19% vs. 3.55%) rates were notably lower with STAT than with CMM. CMM and STAT had significant associations with all outcomes, with overtriages demonstrating lower injury burdens and undertriages showing higher injury burdens than appropriately triaged patients. STAT indicated significantly stronger associations with outcomes than CMM, except in odds of discharge to continuing care facility among patients who received a full trauma team activation where STAT and CMM were similar. CONCLUSIONS: This multicenter study strongly indicates STAT safely and accurately flags fewer cases for triage reviews, thereby reducing the subjectivity introduced by manual triage determinations. This may enable better refinement of activation criteria and reduced workload.
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Centros Traumatológicos , Heridas y Lesiones , Adulto , Niño , Humanos , Puntaje de Gravedad del Traumatismo , Alta del Paciente , Estudios Retrospectivos , Triaje , Carga de TrabajoRESUMEN
BACKGROUND: Early administration of tranexamic acid (TXA) has been widely implemented for the treatment of presumed hyperfibrinolysis in hemorrhagic shock. We aimed to characterize the liberal use of TXA and whether unjustified administration was associated with increased venous thrombotic events (VTEs). METHODS: We identified injured patients who received TXA between January 2016 and January 2018 by querying our Level 1 trauma center's registry. We retrospectively reviewed medical records and radiologic images to classify whether patients had a hemorrhagic injury that would have benefited from TXA (justified) or not (unjustified). RESULTS: Ninety-five patients received TXA for traumatic injuries, 42.1% were given by emergency medical services. TXA was considered unjustified in 35.8% of the patients retrospectively and in 52% of the patients when given by emergency medical services. Compared with unjustified administration, patients in the justified group were younger (47.6 versus 58.4; P = 0.02), more hypotensive in the field (systolic blood pressure: 107 ± 31 versus 137 ± 32 mm Hg; P < 0.001) and in the emergency department (systolic blood pressure: 97 ± 27 versus 128 ± 27; P < 0.001), and more tachycardic in emergency department (heart rate: 99 ± 29 versus 88 ± 19; P = 0.04). The justified group also had higher injury severity score (median 24 versus 11; P < 0.001), was transfused more often (81.7% versus 20.6%; P < 0.001), and had higher in-hospital mortality (39.3% versus 2.9%; P < 0.001), but there was no difference in the rate of VTE (8.2% versus 5.9%). CONCLUSIONS: Our results highlight a high rate of unjustified administration, especially in the prehospital setting. Hypotension and tachycardia were indications of correct use. Although we did not observe a difference in VTE rates between the groups, though, our study was underpowered to detect a difference. Cautious implementation of TXA in resuscitation protocols is encouraged in the meantime. Nonetheless, adverse events associated with unjustified TXA administration should be further evaluated.
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Antifibrinolíticos/uso terapéutico , Prescripción Inadecuada/estadística & datos numéricos , Ácido Tranexámico/uso terapéutico , Tromboembolia Venosa/inducido químicamente , Heridas y Lesiones/tratamiento farmacológico , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios RetrospectivosRESUMEN
We demonstrate a single-photon stored-light interferometer, where a photon is stored in a laser-cooled atomic ensemble in the form of a Rydberg polariton with a spatial extent of 10×1×1µm3. The photon is subject to a Ramsey sequence, i.e., "split" into a superposition of two paths. After a delay of up to 450 ns, the two paths are recombined to give an output dependent on their relative phase. The superposition time of 450 ns is equivalent to a free-space propagation distance of 135 m. We show that the interferometer fringes are sensitive to external fields and suggest that stored-light interferometry could be useful for localized sensing applications.
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We study dispersive optical nonlinearities of short pulses propagating in high number density, warm atomic vapors where the laser resonantly excites atoms to Rydberg P states via a single-photon transition. Three different regimes of the light-atom interaction, dominated by either Doppler broadening, Rydberg atom interactions, or decay due to thermal collisions between ground state and Rydberg atoms, are found. We show that using fast Rabi flopping and strong Rydberg atom interactions, both in the order of gigahertz, can overcome the Doppler effect as well as collisional decay, leading to a sizable dispersive optical nonlinearity on nanosecond timescales. In this regime, self-induced transparency (SIT) emerges when areas of the nanosecond pulse are determined primarily by the Rydberg atom interaction, rather than the area theorem of interaction-free SIT. We identify, both numerically and analytically, the condition to realize Rydberg SIT. Our study contributes to efforts in achieving quantum information processing using glass cell technologies.