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Eur J Pharmacol ; 975: 176637, 2024 Jul 15.
Artículo en Inglés | MEDLINE | ID: mdl-38729416

RESUMEN

Macrophages play a pivotal role in safeguarding against a broad spectrum of infections, from viral, bacterial, fungal to parasitic threats and contributing to the immune defense against cancer. While morphine's immunosuppressive effects on immune cells are extensively documented, a significant knowledge gap exists regarding its influence on macrophage polarization and differentiation. Hence, we conducted a study that unveils that prior exposure to morphine significantly impedes the differentiation of bone marrow cells into macrophages. Furthermore, the polarization of macrophages toward the M1 phenotype under M1-inducing conditions experiences substantial impairment, as evidenced by the diminished expression of CD80, CD86, CD40, iNOS, and MHCII. This correlates with reduced expression of M1 phenotypical markers such as iNOS, IL-1ß, and IL-6, accompanied by noticeable morphological, size, and phagocytic alterations. Further, we also observed that morphine affected M2 macrophages. These findings emphasize the necessity for a more comprehensive understanding of the impact of morphine on compromising macrophage function and its potential ramifications for therapeutic approaches.


Asunto(s)
Diferenciación Celular , Inmunosupresores , Macrófagos , Morfina , Morfina/farmacología , Animales , Macrófagos/efectos de los fármacos , Macrófagos/inmunología , Ratones , Diferenciación Celular/efectos de los fármacos , Inmunosupresores/farmacología , Polaridad Celular/efectos de los fármacos , Óxido Nítrico Sintasa de Tipo II/metabolismo , Ratones Endogámicos C57BL , Fagocitosis/efectos de los fármacos , Activación de Macrófagos/efectos de los fármacos , Masculino , Interleucina-1beta/metabolismo
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