1.
J Am Chem Soc
; 135(31): 11521-4, 2013 Aug 07.
Artículo
en Inglés
| MEDLINE
| ID: mdl-23869694
RESUMEN
The direct, asymmetric α-amination of aldehydes has been accomplished via a combination of photoredox and organocatalysis. Photon-generated N-centered radicals undergo enantioselective α-addition to catalytically formed chiral enamines to directly produce stable α-amino aldehyde adducts bearing synthetically useful amine substitution patterns. Incorporation of a photolabile group on the amine precursor obviates the need to employ a photoredox catalyst in this transformation. Importantly, this photoinduced transformation allows direct and enantioselective access to α-amino aldehyde products that do not require postreaction manipulation.
Asunto(s)
Aldehídos/química , Aminas/química , Aldehídos/síntesis química , Aminación , Aminas/síntesis química , Catálisis , Oxidación-Reducción , Fotones , Estereoisomerismo
2.
Angew Chem Int Ed Engl
; 50(30): 6814-8, 2011 Jul 18.
Artículo
en Inglés
| MEDLINE
| ID: mdl-21671325