Unobtrusive Sensors for Synchronous Monitoring of Different Breathing Parameters in Care Environments.

Respiratory problems are common amongst older people. The rapid increase in the ageing population has led to a need for developing technologies that can monitor such conditions unobtrusively. This paper presents a novel study that investigates Wi-Fi and ultra-wideband (UWB) antenna sensors to simultaneously monitor two different breathing parameters: respiratory rate, and exhaled breath. Experiments were carried out with two subjects undergoing three breathing cases in breaths per minute (BPM): (1) slow breathing (12 BPM), (2) moderate breathing (20 BPM), and (3) fast breathing (28 BPM). Respiratory rates were captured by Wi-Fi sensors, and the data were processed to extract the respiration rates and compared with a metronome that controlled the subjects' breathing. On the other hand, exhaled breath data were captured by a UWB antenna using a vector network analyser (VNA). Corresponding reflection coefficient data (S11) were obtained from the subjects at the time of exhalation and compared with S11 in free space. The exhaled breath data from the UWB antenna were compared with relative humidity, which was measured with a digital psychrometer during the breathing exercises to determine whether a correlation existed between the exhaled breath's water vapour content and recorded S11 data. Finally, captured respiratory rate and exhaled breath data from the antenna sensors were compared to determine whether a correlation existed between the two parameters. The results showed that the antenna sensors were capable of capturing both parameters simultaneously. However, it was found that the two parameters were uncorrelated and independent of one another.

Crescent Antennas as Sensors: Case of Sensing Brain Pathology.

Microstrip crescent antennas offer compactness, conformability, low profile, high sensitivity, multi-band operability, cost-effectiveness and ease of fabrication in contrast to bulky, rigid horn, helical and Vivaldi antennas. This work presents crescent sensors for monitoring brain pathology associated with stroke and atrophy. Single- and multi-element crescent sensors are designed and validated by software simulations. The fabricated sensors are integrated with glasses and experimentally evaluated using a realistic brain phantom. The performance of the sensors is compared in terms of peak gain, directivity, radiation performance, flexibility and detection capability. The crescent sensors can detect the pathologies through the monitoring of backscattered electromagnetic signals that are triggered by dielectric variations in the affected tissues. The proposed sensors can effectively detect stroke and brain atrophy targets with a volume of 25 mm3 and 56 mm3, respectively. The safety of the sensors is examined through the evaluation of Specific Absorption Rate (peak SAR < 1.25 W/Kg, 100 mW), temperature increase within brain tissues (max: 0.155 °C, min: 0.115 °C) and electric field analysis. The results suggest that the crescent sensors can provide a flexible, portable and non-invasive solution to monitor degenerative brain pathology.

Dual-Planar Monopole Antenna-Based Remote Sensing System for Microwave Medical Applications.

Neurodegenerative diseases (NDs) can be life threatening and have chronic impacts on patients and society. Timely diagnosis and treatment are imperative to prevent deterioration. Conventional imaging modalities, such as Computed Tomography (CT), Magnetic Resonance Imaging (MRI), and Positron Emission Tomography (PET), are expensive and not readily accessible to patients. Microwave sensing and imaging (MSI) systems are promising tools for monitoring pathological changes, namely the lateral ventricle enlargement associated with ND, in a non-invasive and convenient way. This paper presents a dual-planar monopole antenna-based remote sensing system for ND monitoring. First, planar monopole antennas were designed using the simulation software CST Studio Suite. The antenna analysis was carried out regarding the reflection coefficient, gain, radiation pattern, time domain characterization, E-field distribution, and Specific Absorption Rate (SAR). The designed antennas were then integrated with a controlling circuit as a remote sensing system. The system was experimentally validated on brain phantoms using a vector network analyzer and a laptop. The collected reflection coefficient data were processed using a radar-based imaging algorithm to reconstruct images indicating brain abnormality in ND. The results suggest that the system could serve as a low-cost and efficient tool for long-term monitoring of ND, particularly in clinics and care home scenarios.

Novel statistical time series data augmentation and machine learning based classification of unobtrusive respiration data for respiration Digital Twin model.

Digital Twin (DT), a concept of Healthcare (4.0), represents the subject's biological properties and characteristics in a digital model. DT can help in monitoring respiratory failures, enabling timely interventions, personalized treatment plans to improve healthcare, and decision-support for healthcare professionals. Large-scale implementation of DT technology requires extensive patient data for accurate monitoring and decision-making with Machine Learning (ML) and Deep Learning (DL). Initial respiration data was collected unobtrusively with the ESP32 Wi-Fi Channel State Information (CSI) sensor. Due to limited respiration data availability, the paper proposes a novel statistical time series data augmentation method for generating larger synthetic respiration data. To ensure accuracy and validity in the augmentation method, correlation methods (Pearson, Spearman, and Kendall) are implemented to provide a comparative analysis of experimental and synthetic datasets. Data processing methodologies of denoising (smoothing and filtering) and dimensionality reduction with Principal Component Analysis (PCA) are implemented to estimate a patient's Breaths Per Minute (BPM) from raw respiration sensor data and the synthetic version. The methodology provided the BPM estimation accuracy of 92.3% from raw respiration data. It was observed that out of 27 supervised classifications with k-fold cross-validation, the Bagged Tree ensemble algorithm provided the best ML-supervised classification. In the case of binary-class and multi-class, the Bagged Tree ensemble showed accuracies of 89.2% and 83.7% respectively with combined real and synthetic respiration dataset with the larger synthetic dataset. Overall, this provides a blueprint of methodologies for the development of the respiration DT model.

Design and Evaluation of Wearable Multimodal RF Sensing System for Vascular Dementia Detection.

Vascular dementia is the second most common form of dementia and a leading cause of death. Brain stroke and brain atrophy are the major degenerative pathologies associated with vascular dementia. Timely detection of these progressive pathologies is critical to avoid brain damage. Brain imaging is an important diagnostic tool and determines future treatment options available to the patient. Traditional medical technologies are expensive, require extensive supervision and are not easily accessible. This article presents a novel concept of low- complexity wearable sensing system for the detection of brain stroke and brain atrophy using RF sensors. This multimodal RF sensing system provides a first-of-its-kind RF sensing solution for the detection of cerebral blood density variations and blood clots at an initial stage of neurodegeneration. A customized microwave imaging algorithm is presented for the reconstruction of images in affected areas of the brain. Designs are validated using software simulations and hardware modeling. Fabricated sensors are experimentally validated and can effectively detect blood density variation (1050 ± 50 Kg/m3), artificial stroke targets with a volume of 27 mm3 and density of 1025-1050 Kg/m3, and brain atrophy with a cavity of 58 mm3 within a realistic brain phantom. The safety of the proposed wearable RF sensing system is studied through the evaluation of the Specific Absorption Rate (SAR < 1.4 W/Kg, 100 mW) and thermal conductivity of the brain (<0.152 °C). The results indicate that the device is viable as an efficient, portable, and low-cost substitute for vascular dementia detection.

Crowdsourced Indoor Positioning with Scalable WiFi Augmentation.

In recent years, crowdsourcing approaches have been proposed to record the WiFi signals annotated with the location of the reference points (RPs) extracted from the trajectories of common users to reduce the burden of constructing a fingerprint (FP) database for indoor positioning. However, crowdsourced data is usually sensitive to crowd density. The positioning accuracy degrades in some areas due to a lack of FPs or visitors. To improve the positioning performance, this paper proposes a scalable WiFi FP augmentation method with two major modules: virtual reference point generation (VRPG) and spatial WiFi signal modeling (SWSM). A globally self-adaptive (GS) and a locally self-adaptive (LS) approach are proposed in VRPG to determine the potential unsurveyed RPs. A multivariate Gaussian process regression (MGPR) model is designed to estimate the joint distribution of all WiFi signals and predicts the signals on unsurveyed RPs to generate more FPs. Evaluations are conducted on an open-source crowdsourced WiFi FP dataset based on a multi-floor building. The results show that combining GS and MGPR can improve the positioning accuracy by 5% to 20% from the benchmark, but with halved computation complexity compared to the conventional augmentation approach. Moreover, combining LS and MGPR can sharply reduce 90% of the computation complexity against the conventional approach while still providing moderate improvement in positioning accuracy from the benchmark.

Microwave sensing dataset for noninvasive monitoring of ventricle enlargement due to Alzheimer's disease.

This paper presents a dataset generated from a comprehensive study on the potential of microwave imaging for early detection or monitoring of different stages of Alzheimer's disease. The study includes collecting and analyzing frequency-domain data using a radar-based head imaging system. The data was obtained from lamb brain phantoms designed to mimic lateral ventricle enlargement, a common symptom of Alzheimer's disease. The article provides detailed descriptions of the data collection method, experimental setup, and different phantoms used. Additionally, the article highlights the importance and potential of the dataset to be used for evaluating and validating new signal processing and imaging techniques. The dataset includes magnitude and phase information for both reflected and transmitted signals making it useful to evaluate radar-based signal processing and imaging techniques. The dataset is open-source and available to the scientific community, providing a valuable resource for researchers to advance their understanding of the potential use of microwave imaging techniques for detecting or monitoring Alzheimer's disease.

Design and Modelling of Graphene-Based Flexible 5G Antenna for Next-Generation Wearable Head Imaging Systems.

Arguably, 5G and next-generation technology with its key features (specifically, supporting high data rates and high mobility platforms) make it valuable for coping with the emerging needs of medical healthcare. A 5G-enabled portable device receives the sensitive detection signals from the head imaging system and transmits them over the 5G network for real-time monitoring, analysis, and storage purposes. In terms of material, graphene-based flexible electronics have become very popular for wearable and healthcare devices due to their exceptional mechanical strength, thermal stability, high electrical conductivity, and biocompatibility. A graphene-based flexible antenna for data communication from wearable head imaging devices over a 5G network was designed and modelled. The antenna operated at the 34.5 GHz range and was designed using an 18 µm thin graphene film for the conductive radiative patch and ground with electric conductivity of 3.5 × 105 S/m. The radiative patch was designed in a fractal fashion to provide sufficient antenna flexibility for wearable uses. The patch was designed over a 1.5 mm thick flexible polyamide substrate that made the design suitable for wearable applications. This paper presented the 3D modelling and analysis of the 5G flexible antenna for communication in a digital care-home model. The analyses were carried out based on the antenna's reflection coefficient, gain, radiation pattern, and power balance. The time-domain signal analysis was carried out between the two antennas to mimic real-time communication in wearable devices.

Evaluation of Unobtrusive Microwave Sensors in Healthcare 4.0-Toward the Creation of Digital-Twin Model.

The prevalence of chronic diseases and the rapid rise in the aging population are some of the major challenges in our society. The utilization of the latest and unique technologies to provide fast, accurate, and economical ways to collect and process data is inevitable. Industry 4.0 (I4.0) is a trend toward automation and data exchange. The utilization of the same concept of I4.0 in healthcare is termed Healthcare 4.0 (H4.0). Digital Twin (DT) technology is an exciting and open research field in healthcare. DT can provide better healthcare in terms of improved patient monitoring, better disease diagnosis, the detection of falls in stroke patients, and the analysis of abnormalities in breathing patterns, and it is suitable for pre- and post-surgery routines to reduce surgery complications and improve recovery. Accurate data collection is not only important in medical diagnoses and procedures but also in the creation of healthcare DT models. Health-related data acquisition by unobtrusive microwave sensing is considered a cornerstone of health informatics. This paper presents the 3D modeling and analysis of unobtrusive microwave sensors in a digital care-home model. The sensor is studied for its performance and data-collection capability with regards to patients in care-home environments.

Low-profile Button Sensor Antenna Design for Wireless Medical Body Area Networks.

A button sensor antenna (BSA) for wireless medical body area networks (WMBAN) is presented, which works through the IEEE 802.11b/g/n standard. Due to strong interaction between the sensor antenna and the body, a new robust system is designed with a small footprint that can serve on- and off-body healthcare applications. The measured and simulated results are matched well. The design offers a wide range of omnidirectional radiation patterns in free space, with a reflection coefficient (S11) of -29.30 (-30.97) dB in the lower (upper) bands. S11 reaches up to -23.07 (-27.07) dB and -30.76 (-31.12) dB on the body chest and arm, respectively. The Specific Absorption Rate (SAR) values are below the regulatory limitations for both 1-gram (1.6 W/Kg) and 10-gram tissues (2.0 W/Kg). Experimental tests of the read range validate the results of a maximum coverage range of 40 meters. Clinical Relevance- WMBAN technology allows for continuous monitoring and analysis of patient health data to improve the quality of healthcare services.

Design of Flexible Meander Line Antenna for Healthcare in Wireless Body Area Network Systems.

A flexible meander line monopole antenna (MMA) is presented in this paper. The antenna can be worn for on-and off-body applications. The overall dimension of the MMA is 37 mm x 50 mm x 2.37 mms, The MMA was manufactured and measured, and the results matched with simulation results. The MMA design shows a bandwidth of up to 1282.4 (450.5) MHz and provides gains of 3.03 (4.85) dBi in two operating bands, respectively, showing omnidirectional radiation patterns in free space. While worn on the chest or arm, bandwidths as high as 688.9 (500.9) MHz and 1261.7 (524.2) MHz, and the gains of 3.80 (4.67) dBi and 3.00 (4.55) dBi were observed. The experimental measurements of the read range confirmed. Clinical Relevance- Wireless Medical Body Area Network (WMBAN) technology allows for continuous monitoring and analysis of patient health data to improve the quality of healthcare services.

Experimental radar data for monitoring brain atrophy progression.

This data set contains complex frequency domain signals obtained from unidirectional antennas mainly fabricated for radar-based head imaging. Data were obtained as part of a project investigating radar-based microwave imaging for monitoring neurodegenerative diseases, especially Alzheimer's disease. The wearable device, measurement setup, and phantoms used are described. Multiple experiments were performed to get the data from three lamb brain phantoms that realistically mimic the whole-brain atrophy due to Alzheimer's disease. Microwave imaging has shown great potential for breast and brain screening due to its low cost, non-ionizing, portable, and wearable nature. Most of the studies are based on simulations with good results, but further evaluation on experimental data is required before its clinical viability. This work provides an open-source experimental dataset that can be used to evaluate novel signal processing and imaging techniques and validate simulation results. The data provide both the magnitude and phase value at each discrete frequency, making this data set useful for both time-delay and phase-shift based imaging algorithms.

In Situ Sensor for the Detection of Oil Spill in Seawater Using Microwave Techniques.

Nearly 30% of oil drilled globally is done offshore. Oil spillage offshore has far-reaching consequences on the environment, aquatic lives, and livelihoods as it was evident in the Deepwater Horizon and Bonga oil spills. A novel microwave in situ oil spill sensor was developed in this work. The device is comprised of two polydimethylsiloxane (PDMS)-encapsulated ultra-wideband underwater microwave trefoil antennas enclosed in a Faraday cage with one serving as the receiving antenna and the other as the transmitting antenna. Heavy aromatic-naphthenic Azeri crude oil was used as an inclusion in the seawater host medium. Substantial changes in the measured reflection (S11) and transmission (S21) coefficients were observed as the medium was adulterated with crude oil starting from 200 MHz to around 2500 MHz. The changes in the dielectric properties of the media resulted in changes in both the S11 and S21 signifying and detecting an occurrence of the oil spillage. Thus, by employing radio frequencies, oil spillage was detected using the in situ monitoring device in seawater.

Intelligent Sensing Technologies for the Diagnosis, Monitoring and Therapy of Alzheimer's Disease: A Systematic Review.

Alzheimer's disease is a lifelong progressive neurological disorder. It is associated with high disease management and caregiver costs. Intelligent sensing systems have the capability to provide context-aware adaptive feedback. These can assist Alzheimer's patients with, continuous monitoring, functional support and timely therapeutic interventions for whom these are of paramount importance. This review aims to present a summary of such systems reported in the extant literature for the management of Alzheimer's disease. Four databases were searched, and 253 English language articles were identified published between the years 2015 to 2020. Through a series of filtering mechanisms, 20 articles were found suitable to be included in this review. This study gives an overview of the depth and breadth of the efficacy as well as the limitations of these intelligent systems proposed for Alzheimer's. Results indicate two broad categories of intelligent technologies, distributed systems and self-contained devices. Distributed systems base their outcomes mostly on long-term monitoring activity patterns of individuals whereas handheld devices give quick assessments through touch, vision and voice. The review concludes by discussing the potential of these intelligent technologies for clinical practice while highlighting future considerations for improvements in the design of these solutions for Alzheimer's disease.

Design, Implementation, and Measurement Procedure of Underwater and Water Surface Antenna for LoRa Communication.

There is an increasing interest in water bodies, which make up more that seventy percent of our planet. It is thus imperative that the water environment should be remotely monitored. Radio frequency (RF) signals have higher bandwidth and lower latency compared to acoustic signals. However, water has high permittivity and conductivity which presents a challenge for the implementation of RF technology. In this work, we undertook a novel design, fabrication, measurement and implementation of an antenna for a sensor node with dual ability of underwater and water surface long range (LoRa) communication at 868 MHz. It was observed that the antenna's performance deteriorated underwater without -10 dB effective bandwidth between 668 MHz and 1068 MHz. The introduction of an oil-impregnated paper buffer around the antenna resulted in an effective 400 MHz bandwidth within the same frequency span. The sensor node with the buffered antenna was able to achieve a distance of 6 m underwater and 160 m over water surface communication to a data gateway node. The sensor node without the buffered antenna was only able to achieve 80 m over water surface communication. These experimental results show the feasibility of using the LoRa 868 MHz frequency in underwater and water surface communication.

Non-Invasive RF Technique for Detecting Different Stages of Alzheimer's Disease and Imaging Beta-Amyloid Plaques and Tau Tangles in the Brain.

This paper describes a novel approach of detecting different stages of Alzheimer's disease (AD) and imaging beta-amyloid plaques and tau tangles in the brain using RF sensors. Dielectric measurements were obtained from grey matter and white matter regions of brain tissues with severe AD pathology at a frequency range of 200 MHz to 3 GHz using a vector network analyzer and dielectric probe. Computational models were created on CST Microwave Suite using a realistic head model and the measured dielectric properties to represent affected brain regions at different stages of AD. Simulations were carried out to test the performance of the RF sensors. Experiments were performed using textile-based RF sensors on fabricated phantoms, representing a human brain with different volumes of AD-affected brain tissues. Experimental data was collected from the sensors and processed in an imaging algorithm to reconstruct images of the affected areas in the brain. Measured dielectric properties in brain tissues with AD pathology were found to be different from healthy human brain tissues. Simulation and experimental results indicated a correlated shift in the captured reflection coefficient data from RF sensors as the amount of affected brain regions increased. Finally, images reconstructed from the imaging algorithm successfully highlighted areas of the brain affected by plaques and tangles as a result of AD. The results from this study show that RF sensing can be used to identify areas of the brain affected by AD pathology. This provides a promising new non-invasive technique for monitoring the progression of AD.

Integrated Flexible Hybrid Silicone-Textile Dual-Resonant Sensors and Switching Circuit for Wearable Neurodegeneration Monitoring Systems.

This paper describes the design, development, and testing of flexible hybrid silicone-textile sensors and a flexible switching circuit that were integrated into a wearable system for monitoring neurodegenerative diseases. A total of 6 planar monopole antenna sensors were fabricated that propagates at two separate resonant frequencies: 800 MHz and 2.1 GHz respectively. In addition, 2 switching circuits, each having 3 switches and 4 SMA breakout boards, were assembled and placed on the wearable neurodegeneration monitoring system. Each switching circuit connects 3 sensors to a single port on a vector network analyzer (VNA) that is used to generate and receive microwave signals. Experiments were performed using the wearable device with the developed sensors and switching circuit on phantoms mimicking two common physiological changes in the brain caused by neurodegenerative diseases: 1) brain atrophy and 2) lateral ventricle enlargement. The dual nature of the sensors' resonance allows it to detect both brain atrophy and lateral ventricle enlargement separately at different operating frequency. This provides the advantage of minimizing the number of sensor elements needed to monitor neurodegenerative disease. The use of a switching circuit also allows for quick and convenient measurements by choosing which sensors are active for ports 1 and 2 on the VNA respectively. In addition to being low-cost, the flexibility of the materials used in fabrication allows the sensors and switching circuit to be conformal to the patient's head. Results from the experiments indicates that the sensors and switching circuit were working successfully when integrated into the wearable device.

A direct-sequence spread-spectrum communication system for integrated sensor microsystems.

Some of the most important challenges in health-care technologies have been identified to be development of noninvasive systems and miniaturization. In developing the core technologies, progress is required in pushing the limits of miniaturization, minimizing the costs and power consumption of microsystems components, developing mobile/wireless communication infrastructures and computing technologies that are reliable. The implementation of such miniaturized systems has become feasible by the advent of system-on-chip technology, which enables us to integrate most of the components of a system on to a single chip. One of the most important tasks in such a system is to convey information reliably on a multiple-access-based environment. When considering the design of telecommunication system for such a network, the receiver is the key performance critical block. The paper describes the application environment, the choice of the communication protocol, the implementation of the transmitter and receiver circuitry, and research work carried out on studying the impact of input data characteristics and internal data path complexity on area and power performance of the receiver. We provide results using a test data recorded from a pH sensor. The results demonstrate satisfying functionality, area, and power constraints even when a degree of programmability is incorporated in the system.