Oral Dantrolene Reduces Myalgia and Hyperckemia in a Child with RYR1-Related Exertional Myalgia/Rhabdomyolysis.

RYR1-related exertional myalgia/rhabdomyolysis (ERM) is an underrecognized condition, which can cause limiting muscle symptoms, and may account for more than one-third of undiagnosed rhabdomyolysis cases. Dantrolene has shown promising results in controlling muscle symptoms in individuals with ERM, however, its use in children remains poorly documented. This case report presents the successful treatment of a 5-year-old patient with ERM using oral dantrolene. The patient experienced notable improvements, including a reduction in the frequency and intensity of myalgia episodes, no hospitalizations due to rhabdomyolysis, a substantial decrease in creatine phosphokinase (CPK) levels, and enhanced performance on the 6-minute walk test. The use of dantrolene was well-tolerated, and no significant adverse effects were observed. This report adds to the existing evidence supporting the effectiveness of oral dantrolene in managing ERM, and, to the best of our knowledge, this is the first report of the use of dantrolene in a pediatric patient for controlling anesthesia-independent muscle symptoms.

Factors associated with burnout syndrome in medical residents of a university hospital.

OBJECTIVE:: To determine the prevalence of burnout syndrome among resident physicians of various specialties and to evaluate associated factors. METHOD:: The Maslach Burnout Inventory questionnaire and a sociodemographic questionnaire were used to evaluate factors associated with the syndrome. Burnout was defined as the association of high emotional exhaustion, depersonalization and low professional achievement. Multivariate analysis was performed after adjustment of the Poisson model with the identification of risk factors and calculation of prevalence ratios (PR). Of the 250 resident physicians registered with Hospital das Clínicas of Pernambuco, 129 participated in the study. RESULTS:: In the three domains that characterize burnout syndrome, we found a low level of professional achievement in 94.6% of resident physicians interviewed, a high level of depersonalization in 31.8%, and 59.7% with a high level of emotional exhaustion. The prevalence of burnout was 27.9%. Having suffered a stressful event in the last six months (PR: 8.10; 95CI 1.2-57.2) and being a student of surgical specialty (PR: 1.99; 95CI 1.2-3.3) were independently associated with burnout. CONCLUSION:: The prevalence of burnout found in resident physicians is in accordance with previous Brazilian studies. Residents of surgical specialties and those who suffered some stressful event were identified as susceptible in this study. The early identification of risk factors is fundamental for the implementation of preventive measures against burnout syndrome.

Factors associated with burnout syndrome in medical residents of a university hospital / Fatores associados à síndrome de burnout em médicos residentes de um hospital universitário

Summary Objective: To determine the prevalence of burnout syndrome among resident physicians of various specialties and to evaluate associated factors. Method: The Maslach Burnout Inventory questionnaire and a sociodemographic questionnaire were used to evaluate factors associated with the syndrome. Burnout was defined as the association of high emotional exhaustion, depersonalization and low professional achievement. Multivariate analysis was performed after adjustment of the Poisson model with the identification of risk factors and calculation of prevalence ratios (PR). Of the 250 resident physicians registered with Hospital das Clínicas of Pernambuco, 129 participated in the study. Results: In the three domains that characterize burnout syndrome, we found a low level of professional achievement in 94.6% of resident physicians interviewed, a high level of depersonalization in 31.8%, and 59.7% with a high level of emotional exhaustion. The prevalence of burnout was 27.9%. Having suffered a stressful event in the last six months (PR: 8.10; 95CI 1.2-57.2) and being a student of surgical specialty (PR: 1.99; 95CI 1.2-3.3) were independently associated with burnout. Conclusion: The prevalence of burnout found in resident physicians is in accordance with previous Brazilian studies. Residents of surgical specialties and those who suffered some stressful event were identified as susceptible in this study. The early identification of risk factors is fundamental for the implementation of preventive measures against burnout syndrome.

Resumo Objetivo: Determinar a prevalência da síndrome de burnout entre médicos residentes de várias especialidades e avaliar os fatores associados. Método: Foram aplicados o questionário Maslach Burnout Inventory e um questionário sócio-demográfico para avaliar fatores associados à síndrome. Burnout foi definido pela associação de alto desgaste emocional e despersonalização e baixa realização profissional. Análise multivariada foi realizada por meio do ajuste do modelo de Poisson com a identificação dos fatores de risco e calculadas as razões de prevalência (RP). Dos 250 médicos residentes cadastrados no Hospital das Clínicas de Pernambuco, 129 participaram do estudo. Resultados: Nos três domínios que caracterizam a síndrome de burnout, encontramos um baixo nível de realização profissional em 94,6% dos médicos residentes entrevistados, alto nível de despersonalização em 31,8% e 59,7% com alto nível de desgaste emocional. A prevalência de burnout encontrada foi de 27,9%. Ter sofrido evento estressante nos seis meses anteriores (RP: 8,10; IC 95% 1,2-57,2) e cursar especialidade cirúrgica (RP: 1,99; IC 95% 1,2-3,3) estiveram associados de forma independente ao burnout. Conclusão: A prevalência de burnout encontrada em médicos residentes está de acordo com estudos brasileiros prévios. Residentes de especialidades cirúrgicas e aqueles que sofreram evento estressor foram identificados como susceptíveis neste estudo. A identificação precoce dos fatores de risco é fundamental para a implementação de medidas preventivas para o não desenvolvimento da síndrome.