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1.
Acta Biomater ; 2024 Jul 04.
Artículo en Inglés | MEDLINE | ID: mdl-38969078

RESUMEN

Osteocytes perceive and process mechanical stimuli in the lacuno-canalicular network in bone. As a result, they secrete signaling molecules that mediate bone formation and resorption. To date, few three-dimensional (3D) models exist to study the response of mature osteocytes to biophysical stimuli that mimic fluid shear stress and substrate strain in a mineralized, biomimetic bone-like environment. Here we established a biomimetic 3D bone model by utilizing a state-of-art perfusion bioreactor platform where immortomouse/Dmp1-GFP-derived osteoblastic IDG-SW3 cells were differentiated into mature osteocytes. We evaluated proliferation and differentiation properties of the cells on 3D microporous scaffolds of decellularized bone (dBone), poly(L-lactide-co-trimethylene carbonate) lactide (LTMC), and beta-tricalcium phosphate (ß-TCP) under physiological fluid flow conditions over 21 days. Osteocyte viability and proliferation were similar on the scaffolds with equal distribution of IDG-SW3 cells on dBone and LTMC scaffolds. After seven days, the differentiation marker alkaline phosphatase (Alpl), dentin matrix acidic phosphoprotein 1 (Dmp1), and sclerostin (Sost) were significantly upregulated in IDG-SW3 cells (p = 0.05) on LTMC scaffolds under fluid flow conditions at 1.7 ml/min, indicating rapid and efficient maturation into osteocytes. Osteocytes responded by inducing the mechanoresponsive genes FBJ osteosarcoma oncogene (Fos) and prostaglandin-endoperoxide synthase 2 (Ptgs2) under perfusion and dynamic compressive loading at 1 Hz with 5 % strain. Together, we successfully created a 3D biomimetic platform as a robust tool to evaluate osteocyte differentiation and mechanobiology in vitro while recapitulating in vivo mechanical cues such as fluid flow within the lacuno-canalicular network. STATEMENT OF SIGNIFICANCE: This study highlights the importance of creating a three-dimensional (3D) in vitro model to study osteocyte differentiation and mechanobiology, as cellular functions are limited in two-dimensional (2D) models lacking in vivo tissue organization. By using a perfusion bioreactor platform, physiological conditions of fluid flow and compressive loading were mimicked to which osteocytes are exposed in vivo. Microporous poly(L-lactide-co-trimethylene carbonate) lactide (LTMC) scaffolds in 3D are identified as a valuable tool to create a favorable environment for osteocyte differentiation and to enable mechanical stimulation of osteocytes by perfusion and compressive loading. The LTMC platform imitates the mechanical bone environment of osteocytes, allowing the analysis of the interaction with other cell types in bone under in vivo biophysical stimuli.

2.
Angew Chem Int Ed Engl ; : e202411298, 2024 Jul 16.
Artículo en Inglés | MEDLINE | ID: mdl-39011619

RESUMEN

The engineering of tunable photoluminescence (PL) in single materials with a full-spectrum emission represents a highly coveted objective but poses a formidable challenge. In this context, the realization of near-full-spectrum PL emission, spanning the visible light range from 424 to 620 nm, in a single-component two-dimensional (2D) hybrid lead halide perovskite, (ETA)2PbBr4 (ETA+ = (HO)(CH2)2NH3+), is reported, achieved through high-pressure treatment. A pressure-induced phase transition occurs upon compression, transforming the crystal structure from an orthorhombic phase under ambient conditions to a monoclinic structure at high pressure. This phase transition driven by the adaptive and dynamic configuration changes of organic amine cations enables an effective and continuous narrowing of the bandgap in this halide crystal. The hydrogen bonding interactions between inorganic layers and organic amine cations (N-H…Br and O-H…Br hydrogen bonds) efficiently modulate the organic amine cations penetration and the octahedral distortion. Consequently, this phenomenon induces a phase transition and results in red-shifted PL emissions, leading to the near-full-spectrum emission. This work opens a possibility for achieving wide PL emissions with coverage across the visible light spectrum by employing high pressure in single halide perovskites.

3.
Heliyon ; 10(13): e33211, 2024 Jul 15.
Artículo en Inglés | MEDLINE | ID: mdl-39035488

RESUMEN

The practical and theoretical significance of the resolvability parameter makes it an important factor, particularly in the context of network analysis. Its significance is seen in various applications and consequences: Network security, efficient routing, social network analysis, facility location, and site selection. This article finds the double resolvability parameters of the fosmidomycin anti-malaria drug. Resolvability parameters like double metric, double edge metric, and double mixed metric dimensions of fosmidomycin anti-malaria drug also hold exchange properties in the molecular graph of fosmidomycin. We convert the molecular structures of fosmidomycin into molecular graphs and then find some resolvability parameters.

4.
J Pak Med Assoc ; 74(7): 1240-1244, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-39028047

RESUMEN

Objectives: To determine the response of various histological types of locally advanced rectal cancer to neoadjuvant multimodality therapy. METHODS: The non-randomised, quasi-experimental retrospective cohort study was conducted at the Combined Military Hospital, Rawalpindi, Pakistan, and comprised data of patients treated between January 1, 2020, to September 30, 2021. The data retrieved related to histologically proven and locally advanced rectal cancer patients aged 18-70 years receiving neoadjuvant chemoradiotherapy. Radiotherapy dose was 45 gray to pelvis with a boost to gross tumour of 5.4 gray in 3 fractions by using volumetric arc therapy concurrently with capecitabine 625mg/m² daily. A magnetic resonance imaging scan of pelvis with contrast was done at 5-10 weeks before surgery. Histological response to neoadjuvant treatment of various histological types was evaluated using the Rectal Cancer Regression Grade. Data was analysed using SPSS 22. RESULTS: Of the 182 patients evaluated, 108(59.34%) were included; 64(59.3%) males and 44(40.7%) females. The overall mean age was 45.4±5.2 years. Regression status was grade 1 in 24(22%) patients, grade 2 in 43(40%) and grade 3 in 41(38%) (p=0.074). There were 12(11.11%) patients with signet ring cell and 10(83.3%) showed pathological tumour regression. There were 17(15.74%) patients with mucinous variant, and 12(70.5%) had tumour regression. There were 79(73.15%) patients with adenocarcinoma, and 59(74.6%) of them showed tumour regression. . CONCLUSIONS: There was less tumour regression in mucinous and signet ring cell variants of adenocarcinoma. Modification and intensification of neoadjuvant therapy may be required in such histologies.


Asunto(s)
Adenocarcinoma , Capecitabina , Terapia Neoadyuvante , Neoplasias del Recto , Humanos , Neoplasias del Recto/terapia , Neoplasias del Recto/patología , Neoplasias del Recto/diagnóstico por imagen , Persona de Mediana Edad , Masculino , Femenino , Terapia Neoadyuvante/métodos , Adulto , Estudios Retrospectivos , Adenocarcinoma/terapia , Adenocarcinoma/patología , Adenocarcinoma/diagnóstico por imagen , Capecitabina/administración & dosificación , Capecitabina/uso terapéutico , Anciano , Pakistán , Quimioradioterapia Adyuvante , Quimioradioterapia/métodos , Imagen por Resonancia Magnética , Carcinoma de Células en Anillo de Sello/terapia , Carcinoma de Células en Anillo de Sello/patología , Carcinoma de Células en Anillo de Sello/diagnóstico por imagen , Adulto Joven , Adenocarcinoma Mucinoso/terapia , Adenocarcinoma Mucinoso/patología , Adenocarcinoma Mucinoso/diagnóstico por imagen
5.
Molecules ; 29(11)2024 Jun 04.
Artículo en Inglés | MEDLINE | ID: mdl-38893531

RESUMEN

In this study, the chemical composition, repellent, and oviposition deterrent effects of five plant essential oils (EOs) extracted from Lantana camara (Verbenaceae), Schinus terebinthifolia (Anacardiaceae), Callistemon viminalis (Myrtaceae), Helichrysum odoratissimum (Asteraceae), and Hyptis suaveolens (Lamiaceae) were evaluated against Aedes aegypti, Anopheles gambiae, and Culex quinquefasciatus. When tested at 33.3 µg/cm2, L. camara, S. terebinthifolia, C. viminalis, and H. odoratissimum were effective repellents against Ae. aegypti (89%, 91%, 90%, and 51% repellency, respectively), but they were less repellent against An. gambiae (66%, 86%, 59%, and 49% repellency, respectively). Interestingly, L. camara, S. terebinthifolia, C. viminalis, and H. odoratissimum exhibited 100% repellency against Cx. quinquefasciatus at 33.3 µg/cm2. In time-span bioassays performed at 333 µg/cm2, the EO of L. camara exhibited 100% repellence against Ae. aegypti and An. gambiae for up to 15 min and against Cx. quinquefasciatus for 75 min. The oviposition bioassays revealed that L. camara exhibited the highest activity, showing 85%, 59%, and 89% oviposition deterrence against Ae. aegypti, An. gambiae, and Cx. quinquefasciatus, respectively. The major compounds of L. camara, S. terebinthifolia, and C. viminalis were trans-ß-caryophyllene (16.7%), α-pinene (15.5%), and 1,8-cineole (38.1%), respectively. In conclusion, the L. camara and S. terebinthifolia EOs have the potential to be natural mosquito repellents.


Asunto(s)
Aedes , Repelentes de Insectos , Aceites Volátiles , Oviposición , Animales , Aceites Volátiles/farmacología , Aceites Volátiles/química , Repelentes de Insectos/farmacología , Repelentes de Insectos/química , Oviposición/efectos de los fármacos , Aedes/efectos de los fármacos , Culex/efectos de los fármacos , Anopheles/efectos de los fármacos , Anopheles/fisiología , Culicidae/efectos de los fármacos , Aceites de Plantas/farmacología , Aceites de Plantas/química , Lantana/química , Anacardiaceae/química , Extractos Vegetales/farmacología , Extractos Vegetales/química , Femenino
6.
RSC Adv ; 14(25): 18011-18063, 2024 May 28.
Artículo en Inglés | MEDLINE | ID: mdl-38847003

RESUMEN

Acyl thioureas represent a privileged moiety with vast potential applicability across diverse fields, making them the subject of extensive research efforts. The inherent flexibility of thiourea facilitates the synthesis of a wide range of core structures with diverse functionalities and properties. The distinctive presence of hard and soft donor sites renders acyl thioureas inclined to act as versatile ligands, thereby engendering a diverse array of metal complexes incorporating acyl thiourea as a pivotal ligand. Extensive investigations into the synthesized acyl thioureas and their derivatives have culminated in the elucidation of their substantial potential across a spectrum of applications, spanning biological activities, materials chemistry, catalysis, and beyond. This literature review represents a continuation of our ongoing endeavor to compile comprehensive data on research endeavors concerning acyl thioureas over the past two years.

7.
Heliyon ; 10(11): e31690, 2024 Jun 15.
Artículo en Inglés | MEDLINE | ID: mdl-38832257

RESUMEN

In recent decades, the randomized response technique has attracted researchers due to its usefulness in sensitive surveys. The randomized response procedure is used for the collection of responses on sensitive issues such as cheating in examination, income earned through illegal sources, expenditure on luxury items, and amount of tax paid, etc. This study introduces a new variant of quantitative randomized response models for use with sample surveys where the variable of interest is quantitative. The properties of a mean estimator based on the new technique have been studied. Further, the combined and separate evaluation metrics for efficiency and privacy level have also been derived and compared with those of the existing methods. Further, a simulation study has been conducted to prove the improvement in the degree of privacy protection and efficiency. The findings reveal that the suggested randomized response technique is not only more efficient than the existing techniques, but also improves the joint measure of efficiency and respondents' privacy, making it preferable over the existing techniques. A real-world example of a sample survey through the suggested model is also presented which illustrates its usefulness in practical surveys on sensitive issues.

8.
Sci Rep ; 14(1): 13301, 2024 06 10.
Artículo en Inglés | MEDLINE | ID: mdl-38858455

RESUMEN

Eigenvalues have great importance in the field of mathematics, and their relevance extends beyond this area to include several other disciplines such as economics, chemistry, and numerous fields. According to our study, eigenvalues are utilized in chemistry to express a chemical compound's numerous physical properties as well as its energy form. It is important to get a comprehensive understanding of the interrelationship underlying mathematics and chemistry. The anti-bonding phase is correlated with positive eigenvalues, whereas the bonding level is connected with negative eigenvalues. Additionally, the non-bonded level corresponds to eigenvalues of zero. This study focuses on the analysis of various structures of anticancer drugs, specifically examining their characteristic polynomials, eigenvalues of the adjacency matrix, matching number and nullity. Consequently, the selected structures of the aforementioned anticancer drugs exhibit stability since they are composed of closed-shell molecules, characterized by a nullity value of zero.


Asunto(s)
Antineoplásicos , Antineoplásicos/química , Antineoplásicos/farmacología , Algoritmos , Humanos , Estructura Molecular , Modelos Teóricos
9.
Sci Rep ; 14(1): 13372, 2024 Jun 11.
Artículo en Inglés | MEDLINE | ID: mdl-38862705

RESUMEN

A relatively recent approach in molecular graph theory for analyzing chemical networks and structures is called a modified polynomial. It emphasizes the characteristics of molecules through the use of a polynomial-based procedure and presents numerical descriptors in algebraic form. The Quantitative Structure-Property Relationship study makes use of Modified Polynomials (M-Polynomials) as a mathematical tool. M-Polynomials used to create connections between a material's various properties and its structural characteristics. In this study, we calculated several modified polynomials and gave a polynomial description of the magnesium iodide structure. Particularly, we computed first, second and modified Zagreb indices based M-polynomials. Randic index, and inverse Randic indices based M-polynomials are also computed in this work.

10.
PLoS One ; 19(5): e0303570, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38781202

RESUMEN

Boron cluster sheets are two-dimensional boron atom-based formations called borophene. They are similar to the two-dimensional sheet known as graphene, which is composed of carbon atoms arranged in a hexagonal lattice. The unique electrical, mechanical, and thermal properties of borophene make it a sought-after substance for a variety of uses, such as catalysis, energy storage, and electronics. There are two ways to manufacture borophene: chemical vapor deposition and molecular beam epitaxy. Vertex-edge valency-based topological descriptors are a great example of a molecular descriptor that provides information on the connection of atoms in a molecule. These descriptions are based on the notion that a node's value in a molecular network is the sum of the valency of those atoms that are directly connected to that node. In this article, we discussed some novel vertex-edge (ve) and edge-vertex (ev) topological descriptors and found their formulations for the boron cluster or borophene sheets. Also, we show the numerical and graphical comparison of these descriptors in this article.


Asunto(s)
Boro , Boro/química , Compuestos de Boro/química , Grafito/química , Modelos Moleculares , Estructura Molecular
11.
PLoS One ; 19(5): e0303848, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38805425

RESUMEN

In this paper, the existence and uniqueness of solution for a fractional differential model involving well-posed boundary conditions and implicit fractional differential equation is considered. The desired goals are achieved by using Banach contraction principle and Scheafer's fixed point theorem. To show the results applicability some examples are presented. The basic mathematical concept of well-posed fractional boundary value issues is investigated in this study. It dives into the existence and uniqueness of these difficulties, offering light on the conditions that allow for both practical and singular solutions. This study contributes to a better knowledge of fractional calculus and its applications in a variety of scientific and technical areas, giving significant insights for both scholars and practitioners.


Asunto(s)
Modelos Teóricos , Algoritmos
12.
PeerJ ; 12: e17191, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38699184

RESUMEN

Context: Exogenous use of potential organic compounds through different modes is a promising strategy for the induction of water stress tolerance in crop plants for better yield. Aims: The present study aimed to explore the potential role of alpha-lipoic acid (ALA) in inducing water stress tolerance in mungbean lines when applied exogenously through various modes. Methods: The experiment was conducted in a field with a split-plot arrangement, having three replicates for each treatment. Two irrigation regimes, including normal and reduced irrigation, were applied. The plants allocated to reduced irrigation were watered only at the reproductive stage. Three levels of ALA (0, 0.1, 0.15 mM) were applied through different modes (seed priming, foliar or priming+foliar). Key results: ALA treatment through different modes manifested higher growth under reduced irrigation (water stress) and normal irrigation. Compared to the other two modes, the application of ALA as seed priming was found more effective in ameliorating the adverse impacts of water stress on growth and yield associated with their better content of leaf photosynthetic pigments, maintenance of plant water relations, levels of non-enzymatic antioxidants, improved activities of enzymatic antioxidants, and decreased lipid peroxidation and H2O2 levels. The maximum increase in shoot fresh weight (29% and 28%), shoot dry weight (27% and 24%), 100-grain weight (24% and 23%) and total grain yield (20% and 21%) in water-stressed mungbean plants of line 16003 and 16004, respectively, was recorded due to ALA seed priming than other modes of applications. Conclusions: Conclusively, 0.1 and 0.15 mM levels of ALA as seed priming were found to reduce the adverse impact of water stress on mungbean yield that was associated with improved physio-biochemical mechanisms. Implications: The findings of the study will be helpful for the agriculturalists working in arid and semi-arid regions to obtain a better yield of mungbean that will be helpful to fulfill the food demand in those areas to some extent.


Asunto(s)
Antioxidantes , Sequías , Fotosíntesis , Ácido Tióctico , Vigna , Vigna/crecimiento & desarrollo , Vigna/efectos de los fármacos , Vigna/metabolismo , Ácido Tióctico/farmacología , Antioxidantes/metabolismo , Fotosíntesis/efectos de los fármacos , Hojas de la Planta/efectos de los fármacos , Hojas de la Planta/crecimiento & desarrollo , Hojas de la Planta/metabolismo , Deshidratación , Clorofila/metabolismo , Peroxidación de Lípido/efectos de los fármacos
13.
Sci Rep ; 14(1): 10816, 2024 May 11.
Artículo en Inglés | MEDLINE | ID: mdl-38734743

RESUMEN

r, s, t-spherical fuzzy (r, s, t-SPF) sets provide a robust framework for managing uncertainties in decision-making, surpassing other fuzzy sets in their ability to accommodate diverse uncertainties through the incorporation of flexible parameters r, s, and t. Considering these characteristics, this article explores sine trigonometric laws to enhance the applicability and theoretical foundation for r, s, t-SPF setting. Following these laws, several aggregation operators (AOs) are designed for aggregation of the r, s, t-SPF data. Meanwhile, the desired characteristics and relationships of these operators are studied under sine trigonometric functions. Furthermore, we build a group decision-making algorithm for addressing multiple attribute group decision-making (MAGDM) problems using the developed AOs. To exemplify the applicability of the proposed algorithm, we address a practical example regarding laptop selection. Finally, parameter analysis and a comprehensive comparison with existing operators are conducted to uncover the superiority and validity of the presented AOs.

14.
J Agric Food Chem ; 72(20): 11682-11693, 2024 May 22.
Artículo en Inglés | MEDLINE | ID: mdl-38739764

RESUMEN

Phytophthora blight of pepper, which is caused by the notorious oomycete pathogen Phytophthora capsici, is a serious disease in global pepper production regions. Our previous study had identified two WRKY transcription factors (TFs), CaWRKY01-10 and CaWRKY08-4, which are prominent modulators in the resistant pepper line CM334 against P. capsici infection. However, their functional mechanisms and underlying signaling networks remain unknown. Herein, we determined that CaWRKY01-10 and CaWRKY08-4 are localized in plant nuclei. Transient overexpression assays indicated that both CaWRKY01-10 and CaWRKY08-4 act as positive regulators in pepper resistance to P. capsici. Besides, the stable overexpression of CaWRKY01-10 and CaWRKY08-4 in transgenic Nicotiana benthamiana plants also significantly enhanced the resistance to P. capsici. Using comprehensive approaches including RNA-seq, CUT&RUN-qPCR, and dual-luciferase reporter assays, we revealed that overexpression of CaWRKY01-10 and CaWRKY08-4 can activate the expressions of the same four Capsicum annuum defense-related genes (one PR1, two PR4, and one pathogen-related gene) by directly binding to their promoters. However, we did not observe protein-protein interactions and transcriptional amplification/inhibition effects of their shared target genes when coexpressing these two WRKY TFs. In conclusion, these data suggest that both of the resistant line specific upregulated WRKY TFs (CaWRKY01-10 and CaWRKY08-4) can confer pepper's resistance to P. capsici infection by directly activating a cluster of defense-related genes and are potentially useful for genetic improvement against Phytophthora blight of pepper and other crops.


Asunto(s)
Capsicum , Resistencia a la Enfermedad , Regulación de la Expresión Génica de las Plantas , Phytophthora , Enfermedades de las Plantas , Proteínas de Plantas , Factores de Transcripción , Phytophthora/fisiología , Enfermedades de las Plantas/microbiología , Enfermedades de las Plantas/genética , Enfermedades de las Plantas/inmunología , Capsicum/genética , Capsicum/microbiología , Capsicum/inmunología , Resistencia a la Enfermedad/genética , Proteínas de Plantas/genética , Proteínas de Plantas/metabolismo , Proteínas de Plantas/inmunología , Factores de Transcripción/genética , Factores de Transcripción/metabolismo , Plantas Modificadas Genéticamente/genética , Plantas Modificadas Genéticamente/microbiología , Plantas Modificadas Genéticamente/inmunología
15.
PLoS One ; 19(4): e0294932, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38603666

RESUMEN

An important dietary source of physiologically active compounds, coffee also contains phenolic acids, diterpenes, and caffeine. According to a certain study, some coffee secondary metabolites may advantageously modify a number of anti-cancer defense systems. This research looked at a few coffee chemical structures in terms of edge locating numbers or edge metric size to better understand the mechanics of coffee molecules. Additionally, this research includes graph theoretical properties of coffee chemical structures. The chemicals found in coffee, such as caffeine, diterpene or cafestol, kahweol, chlorogenic, caffeic, gallotannins, and ellagitannins, are especially examined in these publications.


Asunto(s)
Diterpenos , Neoplasias , Humanos , Café/química , Cafeína , Dieta
16.
Biology (Basel) ; 13(3)2024 Mar 14.
Artículo en Inglés | MEDLINE | ID: mdl-38534455

RESUMEN

Phytophthora blight of pepper is a notorious disease caused by the oomycete pathogen Phytophthora capsici, which poses a great threat to global pepper production. MicroRNA (miRNA) is a class of non-coding small RNAs that regulate gene expressions by altering the translation efficiency or stability of targeted mRNAs, which play important roles in the regulation of a plant's response to pathogens. Herein, time-series mRNA-seq libraries and small RNA-seq libraries were constructed using pepper roots from the resistant line CM334 and the susceptible line EC01 inoculated with P. capsici at 0, 6, 24, and 48 h post-inoculation, respectively. For mRNA-seq analysis, a total of 2159 and 2971 differentially expressed genes (DEGs) were identified in CM334 and EC01, respectively. For miRNA-seq analysis, 491 pepper miRNAs were identified, including 330 known miRNAs and 161 novel miRNAs. Among them, 69 and 88 differentially expressed miRNAs (DEMs) were identified in CM334 and EC01, respectively. Examination of DEMs and their targets revealed 22 regulatory networks, predominantly featuring up-regulated miRNAs corresponding to down-regulated target genes. Notably, these DEM-DEG regulatory networks exhibited significant overlap between CM334 and EC01, suggesting that they might contribute to pepper's basal defense against P. capsici. Furthermore, five selected DEMs (miR166, miR1171, miR395, miR530 and miRN2) and their target genes underwent qRT-PCR validation, confirming a consistent negative correlation in the expression patterns of miRNAs and their targets. This comprehensive analysis provides novel insights into the regulatory networks of miRNAs and their targets, offering valuable contributions to our understanding of pepper's defense mechanisms against P. capsici.

17.
Molecules ; 29(6)2024 Mar 19.
Artículo en Inglés | MEDLINE | ID: mdl-38542997

RESUMEN

The current study aimed to evaluate the presence of chemical variations in essential oils (EOs) extracted from Artemisia scoparia growing at different altitudes and to reveal their antibacterial, mosquito larvicidal, and repellent activity. The gas chromatographic-mass spectrometric analysis of A. scoparia EOs revealed that the major compounds were capillene (9.6-31.8%), methyleugenol (0.2-26.6%), ß-myrcene (1.9-21.4%), γ-terpinene (1.5-19.4%), trans-ß-caryophyllene (0.8-12.4%), and eugenol (0.1-9.1%). The EO of A. scoparia collected from the city of Attock at low elevation was the most active against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa bacteria (minimum inhibitory concentration of 156-1250 µg/mL) and showed the best mosquito larvicidal activity (LC50, 55.3 mg/L). The EOs of A. scoparia collected from the high-altitude areas of Abbottabad and Swat were the most repellent for females of Ae. aegypti and exhibited repellency for 120 min and 165 min, respectively. The results of the study reveal that different climatic conditions and altitudes have significant effects on the chemical compositions and the biological activity of essential oils extracted from the same species.


Asunto(s)
Aedes , Artemisia , Repelentes de Insectos , Insecticidas , Aceites Volátiles , Sesquiterpenos Policíclicos , Scoparia , Femenino , Animales , Aceites Volátiles/farmacología , Aceites Volátiles/química , Repelentes de Insectos/farmacología , Repelentes de Insectos/química , Altitud , Insecticidas/química , Antibacterianos/farmacología , Larva , Aceites de Plantas/química
18.
J Photochem Photobiol B ; 253: 112876, 2024 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-38452453

RESUMEN

Energy has always been the most concerned topic worldwide due to its large consumption. Among various types of energies, light has amazing characteristics and have interesting effects on living organisms. Interest is increasing in the use of laser kernel treatment as an environment friendly physical technique for better results in agronomic crops, but the work is still in progress. The present study was conducted with the aim to examine the application of range of Neodymium-doped Yttrium Aluminum Garnet (Nd:YAG) pulsed laser exposures (200, 400, 600, 800, 1000, 1200, 1400 J/cm2) as pre-sowing kernel treatment on seedling survival rate, leaf photosynthetic activity in relation with photosynthetic pigments and visual morphological effects at seedling to maturity stage. Results showed that the low laser exposure (200, 400 and 600 J/cm2) improved the photosynthetic activity in parallel with improvement in chlorophyll a, chlorophyll b, total chlorophyll, carotenoids as well as morphological traits. Kernel treatments with higher laser fluences (800, 1000, 1200 and 1400 J/cm2) showed irregular responses in studied attributes examined at the individual plant level. At 800 and 1000 J/cm2 improvements were found in some plants but at higher doses clear negative impacts were recorded on studied attributes. In conclusion, the lower doses of Nd:YAG pulsed laser fluences are found beneficial for induction of improvement in maize plants for better growth but higher doses were found toxic ones. In future further studies are needed to check the impacts of low laser doses on yield related attributes under field conditions and the high doses might also be used to create variants with beneficial characteristics if possible.


Asunto(s)
Láseres de Estado Sólido , Láseres de Estado Sólido/uso terapéutico , Zea mays , Clorofila A , Fotosíntesis , Luz , Resultado del Tratamiento
19.
Heliyon ; 10(5): e26992, 2024 Mar 15.
Artículo en Inglés | MEDLINE | ID: mdl-38444503

RESUMEN

The exploration of edge metric dimension and its applications has been an ongoing discussion, particularly in the context of nanosheet graphs formed from the octagonal grid. Edge metric dimension is a concept that involves uniquely identifying the entire edge set of a structure with a selected subset from the vertex set, known as the edge resolving set. Let's consider two distinct edge resolving sets, denoted as Re1 and Re2, where Re1≠Re2. In such instances, it indicates that the graph G possesses a double-edge resolving set. This implies the existence of two different subsets of the vertex set, each capable of uniquely identifying the entire edge set of the graph. In this article, we delve into the edge metric dimension of nanosheet graphs derived from the octagonal grid. Additionally, we initiate a discussion on the exchange property associated with the edge resolving set. The exchange property holds significance in the study of resolving sets, playing a crucial role in comprehending the structure and properties of the underlying graph.

20.
Heliyon ; 10(5): e27488, 2024 Mar 15.
Artículo en Inglés | MEDLINE | ID: mdl-38495208

RESUMEN

In sampling theory, a majority of the available estimators of population variance are designed for use with non-sensitive variables only. Such estimators cannot perform efficiently when the variable of interest is of sensitive nature, such as use of drugs, illegal income, abortion, cheating in examination, the amount of income tax payable, and the violation of rules by employees, etc. In the current literature, the shortage of research studies on variance estimators of a sensitive variable has created a big research gap and a room for improvement in the efficiency of such estimators. In this paper, a new randomized scrambling technique is proposed, along with a new estimator of population variance. The new estimator achieves improvement in efficiency over the available variance estimators. The proposed estimator is designed for use with simple random sampling and uses the information on an auxiliary variable. The improvement in efficiency is shown for different choices of constants. Besides efficiency, improvement in the unified measure of estimator quality is also achieved with the proposed estimator under the new randomized response model.

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