HETEROGENEITY OF CLINICAL MANIFESTATIONS OF HYPERPROLACTINEMIA (REVIEW AND OWN OBSERVATIONS).

The article is devoted to the features of the clinical picture of hyperprolactinemia, which can be partially determined by both gender and age of patients. Along with the well-known "classic" manifestations of hyperprolactinemiс syndrome, such as clinical signs of hypogonadism and mechanical pressure of the pituitary tumor on adjacent anatomical structures, there are others that are poorly known to a wide range of practicing physicians. Less frequent manifestations of hyperprolactinemia include the development of hypopituitarism, osteoporosis or osteopenia, alopecia. The analysis of literature data is illustrated with clinical examples from our own practice. It is noted that the pronounced heterogeneity of the clinical manifestations of hyperprolactinemia determines the need to develop continuity and consistency between doctors of different specialties for timely diagnosis and adequate treatment of this pathology.

[On the groups of maternal support of breast feeding].

The article deals with the data related to the establishment in Russia of public associations of maternal support of breast feeding initiated by the WHO/UNISEF international initiative "Baby friendly hospital". The breast feeding is mostly a concern of medicine and medical institutions of obstetrics and pediatrics and corresponding specialists such as obstetrician-gynecologist, neonatologist and pediatrician. Hence the issue of appropriateness of existence of such groups, their competence and relationship with medical personnel and forms of activity has to be considered From historical point of view, in Soviet health care accumulated very rich experience of effective cooperation of public activists of Russian Red Cross with public health bodies in implementation of preventive and health improving activities, including health education of population groups. The conclusion is made that to provide effective activities of voluntary mothers? Associations to support breast feeding their interaction is needed with medical personnel, the development of scientific-grounded programs of training of mothers-consultants and informational methodical and health education materials.

[Role of the opioid system in prevention of ischemic disorders of cardiac rhythm during adaptation to cold and physical exertion in rats]. / Rol' opiodnoi sistemy v preduprezhdenii ishemicheskikh narushenii ritma serdtsa pri adaptatsii k kholodu i fizicheskoi nagruzke u krys.

It was found that adaptation of rats to cold and physical exercise prevented ventricular fibrillation caused by occlusion of the left anterior coronary artery. Adaptation to cold or only to physical exercise did not prevent ventricular arrhythmias. A significant increase of the beta-endorphin content in the hypophysis and hypothalamus was demonstrated in all adapted rats. An increased content of meth-enkephalin (ME) in the myocardium was found only in rats adapted to cold and physical exercise. It is suggested that increase of the myocardial ME content is of essential significance in the antiarrhythmic action of adaptation.

[Participation of the prostacyclin-thromboxane system in the mechanisms of prevention of arrhythmia caused by occlusion of the coronary artery in adapted rats]. / Uchastie prostatsiklin-tromboksanovoi sistemy v mekhanizmakh preduprezhdeniia aritmii, vyzvannykh koronarookkliuziei u adaptirovannykh krys.

It was found, that adaptation of rats to cold and physical exercise prevented ventricular fibrillation, caused by the occlusion of the left anterior coronary artery. An adaptation to cold only or to physical exercise do not prevent ventricular arrhythmias. An significant increase of prostacyclin/thromboxane index in plasma and heats was estimated in rats adapted to cold and physical exercise in relation to control non-adapted group in condition of functional rest or acute myocardial ischemia. It was assumed that an increase of prostacyclin/thromboxane ratio has a significant role in antiarrhythmic action of adaptation.