Generalized cutaneous morphea in a patient with post-hepatitis C cirrhosis.

A case of generalized cutaneous morphea in a a 55-year-old female patient known to have suffered 10 years from post-hepatitis C virus cirrhosis is reported. Anti-HCV antibodies were present, whereas screening for HBs antigen and anti-HBc antibodies was negative.

[Porokeratosis. A study about 6 cases]. / Porokeratoses: etude de 6 cas.

BACKGROUND: Porokeratoses (PK) represent a less common group of dermatoses that are acquired or hereditary, of unknown pathogenesis, characterized by keratinization disorder. Different clinical forms have been identified and the most frequent are the Mibelli's porokeratosis (MP) and the Disseminated Superficial Actinic Prokeratosis (DSAP). AIM: In this retrospective study, we analysed the observations of PK collected in the Dermatology Department of La Rabta Hospital over a 16-year period. METHODS: Six cases of PK were collected: 4 females and 2 males, with no medical history with a mean-age of 42.7. RESULTS: Only a female patient had (PK) familial history. All our patients had typical clinical aspects with lesions in annular plaques, of atrophic center, surrounded by keratotic border. The histological aspect was consistent with PK, showing the typical cornoid slide. In our series, there are 3 cases of (MP) and 3 cases of (DSAP). PK lesions usually appear during the childhood and the third and fourth decades for the DSAP. In MP, there is one or some large, unilateral, annular plaques. DSAP is characterized by numerous small annular lesions of the photo-exposed regions. Their prognosis is on the whole, favourable but remains conditioned by malignant transformation. Treatment is difficult aiming at reducing that risk of degeneration.

[Pseudoxanthoma elasticum: a report of 11 cases]. / Pseudoxanthome elastique: a propos de 11 observations.

INTRODUCTION: Pseudoxanthoma elasticum (PXE) is an inherited disorder of elastic tissue with many systemic manifestations PATIENTS AND METHODS: We performed a retrospective study from all the patients diagnosed with PXE at the department of dermatology of La Rabta hospital of Tunis, between 1986 and 2003. RESULTS: During the observation period, we identified 11 patients with PXE, 5 males and 6 females with a mean age of 28 years (10-47 years). Family history was found in 5 patients. Exhibit yellowish, pigskin, and popular lesions on the sides of the neck were observed in all cases. Systematic ophthalmologic examination revealed angioïd streaks in 4 patients. No abnormalities were found in cardiovascular and metabolic explorations. DISCUSSION: Diagnosis of PXE is based on clinical, histological and genetic criteria. Ocular and cardiovascular damage make all the gravity of the disease, from where interest of an ophthalmologic and cardiovascular examination systematic.

[Warty dyskeratoma or "follicular dykeratoma": a clinicopathologic features of a new entity]. / Dyskeratome verruqueux ou "dyskeratome folliculaire": aspects anatomo-cliniques d'une nouvelle entité.

INTRODUCTION: Warty dyskeratoma is a rare, benign, epithelial tumor characterized by a variable clinicopathologic spectrum. In all cases, lesions revealed foci of acantholytic dyskeratosis. CASE REPORT: A 74-year-old man has for two year developped a single small nodule with a hyperkeratotic area on the scalp. Histopathology revelead a warty dyskeratoma. DISCUSSION: Warty dyskeratoma is an epithelial tumor. Histopathology is important for the diagnosis. On the basis of our findings and from the literature, we propose to discuss the nosologic problem of this entity.

Genital primary herpetic infection in an infant: clinical features, diagnosis and management.

Genital herpes is a rare disease in infants and is mainly associated with herpes simplex virus (HSV) type 1. Asymptomatic carriers are frequently implicated as transmitters of the disease. Clinical manifestations are the main criteria for diagnosis, However, type-specific serologies and PCR are the most sensitive techniques for detecting HSV. Genital herpes is treated with local or systemic antiviral therapy depending on the severity of the infection. Reducing transmission relies on counseling patients. The disease prognosis is correlated with the underlying immunological status. We report a case of genital primary herpetic infection in an infant.

[Squamous cell carcinoma and discoid lupus erythematosus. Report of 2 cases]. / Lupus discoïde et carcinome épidermoïde. A propos de deux cas.

Some cases of skin cancer developping from chronic discoid lupus erythematosus were publied among the world. We make know our experience about two cases suffering with a chronic discoid lupus erythematosus from 16 and 11 years and developped a squamous cell carcinoma from the elbow and the lower lip.